The Coefficient adaptation problem is often encountered in CFD simulations. The accuracy of simulation results depends much on the empirical Coefficients of mathematical models. Cavitation simulation is a typical application of CFD. Researchers have proposed methods to optimize the empirical Coefficients of the cavitation model. However, these methods can only acquire constant values which aren’ t adaptive to all the operating conditions. This paper focused on the condensation and the evaporation Coefficients of the Zwart model and considered quasi-steady cavitating flows around a 2-D NACA66(MOD) hydrofoil. For the first time, we gave a formal description of the Coefficient adaptation problem, and put forward a method to model the relationship between the best Coefficient values and the operating conditions. We designed and implemented the Coefficient adaptation platform combining OpenFOAM, and validated the best Coefficient values predicted by our method. The overall results show the predicted Coefficient values result in an increase of accuracy by 12% in average, compared with the default values and the tuned values by Morgut, thus indicating our method can effectively solve the Coefficient adaptation problem for the Zwart model. We believe the proposed method can be extended to other mathematical models in practical uses.