Chromosomal DEFECTS are one of the commonest congenital DEFECTS responsible for fetal and neonatal death and handicap. The traditional method of screening for Down’s syndrome has been maternal age where amniocentesis or chorionic villous sampling is offered to women aged 35 years or more. This results in the need for an invasive test in 15-20% of pregnant women with a detection of less than half of the fetuses with Down’s syndrome, because the majority of affected fetuses come from the younger age group. A more effective method of screening is based in the combination of: maternal age, a maternal blood sample for the measurement of the placental products of free b-hCG and PAPP-A and an ultrasound scan at 11-13 weeks; to measure the collection of fluid behind the fetal neck (nuchal translucency), to examine the fetal nose and palate, to measure the fetal heart rate and to assess the flow of blood across the tricuspid valve of the fetal heart and the ductus venosus.This new method of screening reduces dramatically the number of women requiring an invasive test from about 20% to less than 3% and at the same time increases the detection rate of Down’s syndrome and other major chromosomal abnormalities from less than 50% to more than 95%.There are several other benefits of the 11–13 weeks scan as well including: accurate dating of the pregnancy, early diagnosis of many major fetal abnormalities, and the detection of multiple pregnancies with reliable diagnosis of chorionicity, which is the main determinant of the outcome in multiple pregnancies Although there are some markers at second trimester (sonographic and biochemical) to assess risk of chromosomal abnormalities but detection rate is less than first trimester and also early diagnosis ( in first trimester) and early termination is much better regarding patient’s preferences, less complications and less psychological stress.

One of the important issues in understanding hadith is to consider the defective traditions and distinguishing them from sounds traditions. Knowing defective traditions needs exact information and necessary expertise in the knowledge of hadith, and only the specialists in the science of hadith and scholars who are completely familiar with the documents and texts of traditions can distinguish the defective traditions. In this article the different kinds of the causes of hadith and the way of knowing them have been discussed, and some examples of defective traditions are given. The following issues are among the signs of defect in hadith:1. It is narrated only by one person.2. The tradition apparently has a linked chain of transmitters, but during the study it becomes clear some of the transmitters have been omitted.3. The tradition is apparently has connected chain of transmitters, but in fact it is unconnected and connected only in form.4. The text of the hadith is mixed with the text of another tradition or the document of one hadith comes within the document of another tradition.5. The narrator while relating the hadith errs and corrupts the hadith, for example he adds a word or a sentence to the tradition.6. Dividing the tradition in cases where the omitted part and the mentioned part share the same meaning.

A study of various deficiencies observed in the process of pile carpet weaving in the Province of Kashan has revealed that the most important DEFECTS are: unevenness, crimpled sides and erroneous application of the cartoon. Improving weavers' skills will have a significant effect on reducing these DEFECTS.Therefore, weavers should be given educational advice on recognizing the capabilities of looms and other rug weaving equipment, the quality of raw materials and their harmonious use, the correct way of weaving flatwoven rugs, the manner of interlacing the wefts, and daftin-zadan (pounding an iron comb on the weft).

Residual ventricular septal DEFECTS (VSD) are major complications after cardiac surgery. We studied the incidence of this complication, risk factors for its occurrence and short-term follow-up in 179 pediatric patients that underwent surgical closure of VSD from April 2003 until May 2004. All data were gathered retrospectively except measurements of shunt ratio. Studied risk factors included age, sex, weight, height, ejection fraction, VSD size, presence of pulmonary stenosis (PS), responsible surgeon, use of patch material for closing VSD, mean degree of hypothermia, cardiopulmonary bypass and aortic cross-clamp times, hemorrhage, documented infection, and surgical approach for defect closure. The incidence of all residual VSDs was 56% and significant ones (i.e. with Qp/Qs>1.5) 22%. The only statistically significant risk factors were higher age, weigh and height of the patients. There was notable but statistically insignificant differences in residual shunt incidence among the patients of different surgeons and with the use of different patch materials. During the median follow-up period of 9.5 months, 35% of the residual DEFECTS were closed spontaneously. Six patients underwent catheterization, three of which were candidates of residual VSD closure. As residual VSD is a hemodynamically and psychologically important complication, we recommend VSD closure at lower age and the use of intraoperative epicardial or transesophageal echocardiography to minimize its occurrence.