Background and Aim: Major b thalassemia is a hereditary hematologic disease with severe clinical symptoms such as certain organic, skeletal and periodontal difficulties and increase of dental caries rate. The aim of this study was to determine the dental caries rate of Thalassemic children and to compare it with the control groups.Materials & Methods: Sixty b thalassemia and healthy children in three groups, 1-5 years group for DMFT study, 5-12 years for DMFT and DMFT study and after 12 age years for DMFT study were randomly selected. Means of DMFT and DMFT and plaque control indices (the brushing and flossing application) were studied in both groups and between three age groups. Comparisons of results were made using ANOV A and 1.Results: Mean of carious (d, D=4, 5.67) and extracted (m, M=0.22, 0.55) teeth were more in thalassemic patients and mean of filled teeth (f, F=O.45,0.82)were more in control groups. Control group brushed their teeth more frequently and the difference between case and control groups was significant (P<0.05), but there was no significant differences between control and case groups in using dental floss. To summarize, caries rate in both primary and permanent dentition was significantly higher in thalassemic patients comparing to control group (P<0.05).Conclusion: Caries rate is high in both primary and permanent dentition in thalassemic patients. However, there are many contributing factors in the rate of caries in thalassemic children but this study determined lack of adequate dental care as a major factor.