Introduction: Several studies demonstrated an association between dyslipidemia and psychiatric Disorder. The aim of this, study is to evaluate the lipid profile of patients with comorbid generalized anxiety Disorder and major Depressive Disorder.Method: This is a descriptive analytic study of 100 patients (25dn each group: major Depressive Disorder, generalized anxiety Disorder, comorbid anxiety and Depressive Disorder and control subjects according to DSM-IV). The demographic characteristics were recorded and blood sampling for lipid profile was. performed. Beck and Kattle inventory questionnaires were completed.Results: Seventy-five percent of patients were female. Total cholesterol, triglyceride and low-density lipoprotein cholesterol levels are significantly higher and high-density lipoprotein cholesterol level was lower in patients with comorbid anxiety and Depressive Disorder than the other groups. Discussion: Dyslipidemia in patients with comorbid anxiety and Depressive Disorder is considerable high. Lipid profile screening in such patients is recommended.