A LARGE NUMBER OF BARBITURIC ACID DERIVATIVES HAVE BEEN WIDELY USED AS SEDATIVE, HYPNOTIC, ANTISPASMODIC, ANTICONVULSANT AND LOCAL ANAESTHETIC DRUGS AS WELL AS IN ANTITUMOR, ANTICANCER AND ANTIOSTEOPOROSIS TREATMENTS [1-5]. IN THIS RESEARCH, WE REPORT SYNTHESIS OF SOME NEW AZO DYES CONTAINIG OF BARBITORATE RINGS.4-AMINO HIPPURIC ACID WAS DIAZOTISED AND COUPLED WITH BARBITORIC ACID AND 2-THIOBARBITORIC ACID. THEN, THE PRODUCT REACTED WITH AROMATIC ALDEHYDE, SODIUM ACETATE AND ACETIC ANHYDRIDE AND OXAZOLONE RING WAS FORMED.SOLVATOCHROMIC BEHAVIOR OF THESE DYES WERE STUDIED IN THE ETOH, DMSO AND DMF. THE STRUCTURES OF PRODUCTS WERE CONFIRMED BY FT-IR, 1H NMR, 13C NMR AND MASS SPECTRA.

BACKGROUND: TODAY’S INCREASING GLOBAL DEMAND FOR ENERGY HAS CAUSED A POWERFUL NEED FOR SUBSTITUTING ENERGY SOURCES WHICH ARE INEXPENSIVE AND ECO-FRIENDLY. RENEWABLE ENERGY TECHNOLOGIES SUCH AS SOLAR POWERS CAN HELP US ELIMINATING THESE NEEDS. …

IN RECENT YEARS INCREASING ATTENTION HAS BEEN FOCUSED ON THE WIDESPREAD USE OF SYNTHETIC DYES, ESPECIALLY IN FOOD AND COSMETICS, BECAUSE OF THEIR POTENTIAL TOXICITY. IN REPUBLIC OF CHINA, THE FIRST GROUP OF 65DYES CAN BE USED IN COSMETICS, THE SECOND GROUP INCLUDING 25 DYES IS NOT ALLOWED TO BE USED IN MUCOUS COSMETICS. IN THIS STUDY WE EXPECTED TO SEPARATE AND IDENTIFY 25 DYES IN THE SECOND GROUP AS WELL AS AMARANTH (RED NO 2) WHICH WAS EXCLUDED IN USE FOR COSMETICS DUE TO SAFETY CONSIDERATION BY DEVELOPING A HPLC METHOD. ILLEGAL COAL TAR DYES ARE REPORTED TO POSSESS STRONG TOXICITY AND CARCINOGENICITY WHEN ADDED IN MUCOUS COSMETICS. LIPSTICK IS CLASSIFIED INTO THE SECOND CATEGORY BASED ON CHINES NATIONAL STANDARD (CNS) IN MUCOUS COSMETICS, IN ADDITION TO WAX LIPIDS, COLORING DYES ARE THE MOST IMPORTANT INGREDIENTS OF LIPSTICK, THE NEWLY DEVELOPED METHOD WAS USED TO ESTABLISH AN ANALYTICAL METHOD TO SIMPLIFY EXTRACTION AND IDENTIFICATION PROCEDURES FOR ANALYZING COLORING DYES IN COMMERCIAL LIPSTICK IN ORDER TO CHECK FOR ILLEGAL COLORING DYES.THE COLORANTS WERE EXTRACTED FROM THE COSMETIC PRODUCTS THROUGH TWO METHOD, ONE OF THEM WAS ADSORPTION OF CONTAMINANTS BY MACS) MAGNETIC ACTIVATED CARBONS) AND MAGNETIC SEPARATION AND ANOTHER ONE WAS LIQUID-LIQUID EXTRACTION THEN RE-EXTRACTED USING A COTTONDYEING PROCESS; THESE TWO METHODS USED FOR PRE-CONCENTRATION AND EXTRACTION OF COLORING DYES BOTH GREATLY IMPROVED ANALYTICAL EFFICIENCY AND PRECISION AND THE LIMIT OF DETECTION, FURTHERMORE TBA-BR WAS SELECTED AS ION-PAIR REAGENT IN THIS STUDY. RESULTS SHOWED THAT CAPACITY FACTORS OF DYES WERE IMPROVED WITH INCREASING TBA-BR CONCENTRATION WHICH THE OPTIMUM CONCENTRATION OF TBA-BR WAS FOUND TO BE 0.01 M. IN THIS STUDY WE USED HPLC WITH OPTIMAL CONDITIONS USING C18 COLUMN WITH THE MOBILE PHASE USING 0.07 M AMMONIUM ACETATE SOLUTION IN0.01 TETRABUTYLAMMONIUM BROMIDE /METHANOL/ACETONITRILE55: 35: 10 AND COLORANTS WHICH WERE ANALYZED BY HPLC FOLLOWED BY DAD DETECTOR. A WAVELENGTH AT 520 NM WAS FOUND TO BE MOST FAVORABLE FOR THE DETECTION OF RED COLOR, A MAJOR COLOR WIDELY APPLIED ON LIPSTICKS AND A WAVELENGTH AT 254 NM, WHICH BELONGED TO UV ABSORBANCE WAVELENGTH NORMALLY ABSORBED BY COAL TAR DYES, WAS USED TO DETECT THE COLOR OTHER THAN RED SUCH AS GREEN, ORANGE, YELLOW, BLACK, AND PURPLE IN COLOR. BY APPLYING THIS HPLC METHOD ALONG WITH THE ABOVE-MENTIONED PROCEDURE, WATER SOLUBLE COAL TAR DYE CONSTITUENTS CAN BE SATISFACTORILY SEPARATED WITH OTHER PREVIOUSLY MENTIONED PROFITS.

BACKGROUND: SPIROPYRANS ARE A FAMILY OF PHOTOCHROMIC COMPOUNDS THAT CAN BE REVERSIBLY SWITCHED BETWEEN TWO STATES: A COLOURLESS, NON-POLAR, UNCHARGED SPIRO FORM (SP) AND A HIGHLY COLOURED, POLAR, CONJUGATED, ZWITTERIONIC MEROCYANINE FORM (MC). THESE MATERIALS HAVE ATTRACTED MUCH ATTENTION RECENTLY BECAUSE OF THEIR POTENTIAL APPLICATIONS AS OPTICAL FILTERS, OPTICAL SWITCHES [1], OPTICAL MEMORIES [2]...