Background: Previous studies have shown that embryo DONATION can be a successful treatment for infertile couples, however the willingness of Dutch couples to donate or accept EMBRYOS was unknown. The aim of this article is to describe the protocol and results for altruistic embryo DONATION of the only embryo bank in the Netherlands. Materials and Methods: This is a descriptive study. Since 2011, donated cryo-EMBRYOS from couples that have undergone in vitro-fertilization/intracytoplasmic sperm injection (IVF/ICSI) treatments, are being stored in our embryo bank. The majority of the donated EMBRYOS were frozen on day 3 or 4 by slow freezing techniques. We perform a thorough medical and psychological screening of donor couples and recipients, according to the protocol drawn up in close collaboration with the Dutch Ministry of Health. Results: Up to June 2021, 54 women have received EMBRYOS from our embryo bank, all single embryo transfers. While the clinical pregnancy rate in ‘ unknown’ embryo DONATIONs was relatively high (25. 3%), the live birth rate shows limited success (12. 6%), partly due to high pregnancy loss through miscarriage. In known DONATION procedures, the recipients tend to undergo more procedures, depending on the number of donated cryo-EMBRYOS. Twentyeight women received EMBRYOS from known donors, with a clinical pregnancy rate per embryo transfer of 24%, and live birth rate of 14%. In total, 82 recipients were granted donated cryo-EMBRYOS, twenty had an ongoing pregnancy (24. 4%), nineteen of whom have given birth to a healthy child (23%). Conclusion: Altruistic embryo DONATION of EMBRYOS appears to be satisfying for the donors, as they are not obliged to destroy their EMBRYOS, but instead help others build a family. Although success rates are still limited, partly due to the relatively high miscarriage rates and inferior freezing techniques, to this date nineteen out of 82 recipients have given birth to a healthy child.

So far, more than 2 million babies have been born worldwide through assisted reproductive technologies (ART). For many couples there is no treatment except joining a third party to the family. Recently, embryo DONATION law has been approved by Iran’s parliament and now it is legal in Iran. But there is a misunderstanding in the source of EMBRYOS: from surplus frozen EMBRYOS of infertile couples and sperm and egg DONATION from fertile married couples followed by DONATION of the resulting EMBRYOS. Here in this paper we discussed ethical, religious and legal aspects of these two procedures and present the advantages and disadvantages of them. Meanwhile, the new term "both gamete DONATIONs" was defined for the misplaced program instead of "embryo DONATION". In conclusion we can say: 1) Iranian law means only embryo DONATION and covers only surplus EMBRYOS from other infertile couples and not both gamete DONATION. 2) As gamete DONATION is practiced in Iran upon decrees of clergy leaders, there is nothing against both gamete DONATIONs. 3) There are so many ethical, legal and religious questions about "both gamete DONATION" to be answered. 4) Ethical and religious questions are very fewer about "embryo DONATION" comparing to "both gamete DONATION" program, and 5) Embro sharing is a good way for DONATION of fresh EMBRYOS.