EPILEPSY is the third most common neurological disorder in the world, affecting more than 70 million people (about 1%) [1]. EPILEPSY is a series of chronic neurological disorders with heterogeneous symptoms that are characterized by recurrent spontaneous seizures. Seizures are transient signs or symptoms that occur in neurons in a part of the brain as a result of increased and at the same time unusual activity [1, 2]. Seizures are not called EPILEPSY until they become chronic [2]. The mechanism of development and development of EPILEPSY is not well known to date. EPILEPSY is a complex malformation of the brain that results from injury and bleeding in the brain. Following these changes in the healthy brain, recurrent seizures occur [9]. EPILEPSY is a slow process, which lasts for several months until spontaneous seizures occur [10]. Complex mechanisms of EPILEPSY and seizures cannot be identified using clinical studies in humans alone. Therefore, the use of appropriate animal models seems necessary [5]. This article tries to introduce the types of EPILEPSY, the process of EPILEPSY and the mechanism of EPILEPSY.

Recent advances in our knowledge of the basic mechanisms of EPILEPSY have derived from increasing ability to carry out detailed investigations on patients surgically treated for refractory EPILEPSY. Clinical as well s experimental perioperative investigations divide into three phases: before the surgical intervention (pre-operative studies), during the surgical intervention (intra-operative studies), and on the period when the brain tissue that has to be removed is available for further studies (post-operative studies). Before surgery, structural and functional neuroimaging methods could be used to study the pathophysiological mechanisms of seizures in patients with intractable EPILEPSY. During EPILEPSY surgery, it is possible to insert electroencephalogram electrodes and microdialysis probes into the brain tissues to evaluate constituents of micromilieu and study brain bioelectrical activities. Surgical resection provides tissue that can be used for electrophysiological, morphological, and molecular biological investigations. To take advantage of these opportunities, carefully designed experimental and clinical protocols are crucial to compare the data from various studies to characterize abnormalities in the epileptic brain in order to improve our understanding of intractable EPILEPSY as well as brain function.

Background and Objectives: EPILEPSY is a chronic condition results in seizure and leads to debilitating conditions in patients. EPILEPSY self-management behaviors include activities to manage the disease. The aim of this study was to assess self-management behaviors and its correlation with seizure frequency in patients with EPILEPSY.Materials and Methods: In this correlation study, 120 patients with EPILEPSY were selected from Iran EPILEPSY Association using convenience sampling method. Data were collected using a demographic checklist, Dilorio’s EPILEPSY self-management behaviors scale and a checklist to record the number of seizures. Data were analyzed in the SPSS-16 using the correlation coefficient.Results: The mean score of the self-management behaviors was 118.05±21.54. The highest score was in the area of seizure management (79.9) and the lowest score was in the area of drug management (57.56). There was a significant relationship between the EPILEPSY self-management behaviors and the frequency of seizures in patients with EPILEPSY (r=-0.3; P<0.001).Conclusion: The frequency of self-management behaviors was moderate. In patients with higher self-management behaviors score, seizures frequency was found to be lower.