An environmentally benign and efficient process for the preparation of b-hydroxysulfides was developed by a practical and simple reaction of thiols with EPOXIDEs in water catalyzed by K2CO3 in high yields and short reaction times.

To combine the properties of degradability and low critical solution temperature transition in a single macromolecule, a new thermoresponsive polyester with oligo (ethylene glycol) side chains was designed. This particular polymer P (ME2MO-alt -SA) was prepared by alternating ring-opening copolymerization of functionalized EPOXIDE [2- ((2- (2-methoxyethoxy) ethoxy) methyl) oxirane, ME2MO] and succinic anhydride (SA) in bulk using metallic alkoxide as initiator. The effects of various kinetics conditions on ME2MO–SA copolymerization, such as initiator, polymerization time, temperature, monomer/initiator ratio, and feed ratio, are discussed in detail. The formation of an alternative structure is demonstrated and the conditions for ME2MO–SA copolymerization are optimized: aluminum isopropoxide (AIP) as initiator; monomer/initiator molar ratio (M/I) at 150; the feed ratio of comonomers at 0.5; polymerization temperature at 120oC more than 12 h. From the NMR spectra, the initiation end group is confirmed to be isopropanol ester that results from the initiation reaction of AIP with SA. However, the termination end group was variable and could be hydroxyl, carboxyl or their mixture, depending on the feed ratio of ME2MO/SA. Based on the above experimental results, the possible coordination–insertion mechanism was proposed for alternating ring-opening copolymerization of ME2MO and SA initiated by AIP, which suggested the two monomers are inserted into the O-Al and COO-Al active ends alternately.

Soluble EPOXIDE Hydrolase (sEH) enzyme converts Epoxyeicosatrienoic acids (EETs), substrates formed by epoxygenases from arachidonic acid, to the corresponding diols. EETs have a wide range of physiological effects. Among them, vasodilatory actions in vascular conduit, renal afferent arterioles, and coronary vessels are more considerable and lead to the regulation of blood pressure and myocardial perfusion. In addition, EETs modulate adhesion molecule expression, platelet aggregation, vascular smooth muscle cell migration, and thrombolytic properties, which could be involved in a protective mechanism against athero 5 sclerosis. Therefore, sEH inhibition that leads to the accumulation of active EETs, provides a novel approach to the treatment of hypertension and atherosclerosis. Since the most reported potent sEH inhibitors have limited pharmacokinetic profile, they aren’ t useful for clinical application. The effort to achieve to sEH inhibitors with proper potency and enhanced pharmacokinetic properties is still continuous. In this study, new urea-based compounds with oxadiazole ring against sEH enzyme were developed. The designed compounds showed a high affinity to the active site of the sEH enzyme and were synthesized in good yield and characterized by IR, Mass, and 1HNMR. Some novel compounds had comparable in vitro sEH inhibitory activity to 12-(3-Adamantan-1-yl-ureido)-dodecanoicacid (AUDA), a potent urea-based sEH inhibitor.