Background: One of present prevalent diseases in world provice is depression. At the present time, synthetic medicines drugs available are not very effective in the treatment of the disease.Aim: Access to a non-drug treatment method for the disease.Methods: We used 50 rats in 5 different groups (n=10).We injected 0.5 ml of physiologic serum and 0.5 ml reserpin solution in peritoneum (IP) to groups 1 and 2 respectively. After two hours, group two rats were depressed, these animals inflicted to eyes bleeding, diarrhea, feet bleeding, and tranquility and their righting reflex were very week. We injected reserpin to groups 3, 4 and 5 similar to group two. Hence from the second day, after injection these groups were placed in an electromagnetic field with the intensity of 250 microtesla constantly under 25, 50 and 100Hz frequencies. The depression signs in groups 3, 4, 5 and group 2 were evaluated daily. Therefore, each rat received certain points with respect to the signs demonstrated. Meanwhile, mortality in some groups, especially in group 2 occurred.Result: Statistical analysis of findings showed that electromagnetic field with 25, 50 and 100Hz depression signs with respect to blank group (only reserpin group) was reduced, and this reduction for electromagnetic field with the frequency of p<0.05 and for the field with 25Hz with p<0.05 and for the field with N=100Hz to place after a period of one week.