Background: Several studies have indicated that compared to non-FAMILIAL marriage, FAMILIAL marriage would increase the incidence of congenital abnormalities. Since the rate of consanguinity marriage is high in our country, this study was performed to determine the prevalence of congenital anomalies between FAMILIAL and non-FAMILIAL marriage. Materials and Methods: For this analytic descriptive study, 928 couples were participated as the population of this investigation. Of them, 358 were FAMILIAL-marriage couples and 570 were non-FAMILIAL-marriage couples. We evaluated the variables such as parent's age, FAMILIAL and non-FAMILIAL marriage rate and rates of congenital abnormalities between both groups. Both the questionnaire and face to face interview technique were applied in this study. Results: Congenital anomalies were identified in 26 (7.26%) children of FAMILIAL marriage group and 11(1.92%) ones in non-FAMILIAL marriage group. The average rate of consanguineous marriage in this study was found to be 38.57%. Conclusion: Considering that the rate of congenital anomalies in FAMILIAL marriage was more than that of non-FAMILIAL marriage, it seems that it is essential to consult and teach families and young couples about the risks of FAMILIAL marriage.

FAMILIAL homozygous hypercholesterolemia is a rare genetic disorder. The low-density lipoprotein (LDL) and cholesterol levels are elevated enormously and are resistant to diet therapy or common drug therapy for hyperlipidemia. New hopes have emerged with plasmapheresis, LDL apheresis and liver transplantation. This is a case report of a 14 year-old boy with FAMILIAL homozygous hypercholesterolemia not responsive to different types of drugs. At angiography, the patient had multiple atherosclerotic lesions throughout the coronary arteries. After 5 courses of phasmapheresis the total cholesterol and LDL levels decreased by 43% and 40%, respectively, and the patient s symptoms also improved. But as LDL apheresis is not available in our country and not many liver transplantations have yet been performed, it is not known whether to continue the plasmapheresis sessions, and with this is there any hope for the regression of the progressed progressed athero sclerotic lesions (Iranian Heart Journal 2003; 4 (2,3): 77-79).

Purpose: To report a relatively rare case of FAMILIAL exudative vitreoretinopathy (FEVR).Patient and Findings: A 13-year-oldboy referred with decreased visual acuity of both eyes, specially right eye from 6 years ago. He had several ophthalmologist and optometrist visits and spectacle prescription without any improvement of vision. Best corrected visual acuity (BCVA) was 25 cm of count finger in right eye and 10/10in left eye. Right eye had +2 APD without positive finding on slit-lamp examination. Blurred optic disk margin with large and diffuse exudates involing macular region and avascular zone, especially on temporal side with fibrovascular tissue between avascular zone were detected on funduscopy in the right eye. Following several laboratory examination, diagnosis of FEVR was determined and patient underwent full panretinal photocoagulation.Conclusion: Early detection of FEVR plays an important role on preventing the progression of the diseases and improving the vision of patient and his/her family.