Crying is normal physiological behavior in early infancy and peaks at 6 wks age. Excessive crying is defined as crying>3 hours / day for>3 days/wk mostly during evening hours and often referred to as colic. Two most prevalent differential diagnoses of colic are GERD and food allergy. In clinical setting, we are engaging to decide whether it is infant colic which needs only assurance to parents or it is irritability arising from acid induced or allergic esophagitis which needs sophisticated intervention.It assumes in absence of prominent vomiting, diarrhea, poor weight gain, feeding difficulties (coughing, gagging, refusal to eat) and eczema, prescribing acid suppressors or switching formula and maternal diet is not generally effective.