Background: HAND ECZEMA is one of the most common dermatologic diseases requiring treatment but common therapeutics such as corticosteroids and anti-histamines have numerous side effects.So, use of herbal agents, which generally have no major side effects, may be useful especially if their efficacy is established.Malva Sylvestris (MS) is a tropical plant in Iran with cooling characteristics. Hence, in this study, its efficacy in of the treatment of HAND ECZEMA was evaluated.Methods: In this randomized clinical trial, 50 patients with HAND ECZEMA who were visited at Shohada-e Tajrish and Loghman hospitals, Tehran, Iran, between 2006 and 2008, were recruited and divided into two groups. In the first group, MS 4% ointment was applied twice a day and in the other group, placebo ointment was usd. The efficacy and side effects were evaluated three and six weeks after beginning of the treatment.Results: Mean age of the patients was 37.3 years and 35.6 years in MS and placebo groups, respectively (P>0.05). There were no therapeutic adverse effects in the groups. There was a statistically significant difference in all measured scores between two groups in the first and second follow-up sessions (P<0.0001).Conclusion: Malva Sylvestris seems to be a safe and effective therapeutic modality for the treatment of HAND ECZEMA and can be used as an optimal substitute for corticosteroids and antihistamines.

The coronaviruses are the family of single-stranded ribonucleic acid (RNA) viruses which are named because of their crown-shaped glycoprotein envelope structure. The coronavirus 2019 (COVID-19) is the “ novel” member of the family and its epidemic spread originated in Wuhan, China via animal-to-human transmission. Similar to the other members of the family, the novel coronavirus causes respiratory symptoms ranging from mild to severe (1). Thus, it is suggested that COVID-19 transmission is through the respiratory droplets that carry the virus. In special cases, it can also happen via aerosol transmission (2). . . .

Background & Objective: HAND contact dermatitis, with a one-year frequency of up to 10% and a lifetime prevalence of nearly 15% in the general population, typically involves inflammation of the dermis and epidermis layers .The aim of this study was to investigate and emphasize the anti-inflammatory properties of flaxseed oil as well as its historical use in traditional medicine, which could help support its potential effectiveness in treating HAND ECZEMA and improving the quality of life of patients.  Materials & Methods: The research conducted was a triple-blind, randomized controlled trial involving 68 patients diagnosed with mild to moderate ECZEMA. The participants were assigned to receive either 1 gram of topical flaxseed oil applied twice daily or a control cream, Eucerin, over a period of four weeks. The effectiveness of the treatment was evaluated by measuring the severity of ECZEMA and the quality of life of the patients before and after the intervention. This assessment was carried out using the HAND ECZEMA Harshness Index (HECSI) and the Dermatology Life Quality Index (DLQI). Results:  Based on the gas chromatography (GC) analysis, the flaxseed oil contained 1.9 grams of linoleic acid per 100 grams of oil. There was no substantial variance in the baseline demographic and clinical characteristics of the two study groups. HECSI and DLQI(14.71 ± 1.89) scores significantly improved in the flaxseed oil group compared to the control group (p=0.001). This effect was particularly pronounced among patients with mild and moderate ECZEMA (p<0.001). Conclusion:  Flaxseed oil can improve ECZEMA indications and quality of life in contact dermatitis patients. However, further research with a larger sample size and comparison to topical steroids is recommended.  Keywords: Flaxseed oil, Dermatitis, Herbal medicine, Persian medicine Background & Objective: HAND contact dermatitis, with a one-year frequency of up to 10% and a lifetime prevalence of nearly 15% in the general population, typically involves inflammation of the dermis and epidermis layers .The aim of this study was to investigate and emphasize the anti-inflammatory properties of flaxseed oil as well as its historical use in traditional medicine, which could help support its potential effectiveness in treating HAND ECZEMA and improving the quality of life of patients.  Materials & Methods: The research conducted was a triple-blind, randomized controlled trial involving 68 patients diagnosed with mild to moderate ECZEMA. The participants were assigned to receive either 1 gram of topical flaxseed oil applied twice daily or a control cream, Eucerin, over a period of four weeks. The effectiveness of the treatment was evaluated by measuring the severity of ECZEMA and the quality of life of the patients before and after the intervention. This assessment was carried out using the HAND ECZEMA Harshness Index (HECSI) and the Dermatology Life Quality Index (DLQI). Results:  Based on the gas chromatography (GC) analysis, the flaxseed oil contained 1.9 grams of linoleic acid per 100 grams of oil. There was no substantial variance in the baseline demographic and clinical characteristics of the two study groups. HECSI and DLQI(14.71 ± 1.89) scores significantly improved in the flaxseed oil group compared to the control group (p=0.001). This effect was particularly pronounced among patients with mild and moderate ECZEMA (p<0.001). Conclusion:  Flaxseed oil can improve ECZEMA indications and quality of life in contact dermatitis patients. However, further research with a larger sample size and comparison to topical steroids is recommended.

Background: Palmoplantar psoriasis (PPP) and hyperkeratotic ECZEMA (HPKE) are common and troublesome entities affecting the palms and soles. The diagnosis is made clinically, but differentiation is difficult,histopathology helps but is often impossible in daily practice. Dermoscopy is increasingly utilized to diagnose inflammatory disorders and has been used to differentiate PPP from HPKE. The present study was carried out to evaluate the role of dermoscopy in the differentiation of PPP and HPKE in a tertiary care center of eastern India. Methods: This hospital-based observational study included 20 patients with each of clinically diagnosed PPP and HPKE. Dermoscopy examinations were done, and the results were tabulated and summarized. Fisher’, s exact test was employed to assess statistical significances in differences. Results: Diffuse white and yellow scales were found in both PPP and HPKE without any significant difference. Brown orange globules, clustered dotted vessels, yellow, orange crusts, and perilesional scaling were found more in HPKE (P < 0. 05). On the other HAND, uniformly dotted vessels and background erythema were more characteristic of PPP (P < 0. 05). The results of the current study had deviations from the results of studies done abroad, which can be ascribed to differences in skin color. Conclusion: Dermoscopy is a valuable tool to sort out diagnostic dilemmas in cases of PPP and HPKE. It should be used more commonly to gain more experience and information in the diagnosis of inflammatory dermatoses.