Treatment of diseases with natural remedies is gaining popularity because of fewer side effects. A sys temic and scientific investigation of aqueous extract of Euphorbia tirucalli for its antioxidant and hepato protective potential against carbon-tetrachloride-induced hepatic damage in rats was carried out. Antioxi dant property was assessed by using reducing property, superoxide anion scavenging and hydroxyl radi cal scavenging property. Hepato-protective property was assessed by measuring the extent of reversal of enhanced biochemical markers of hepatitis, like sSerum glutamate pyruvate transaminase, serum gluta mate oxaloacetate transaminase, alkaline phosphatase ALP, biluribin, cholesterol, triglycerides and also by estimating the tissue glutathione (GSH) levels and the extent of reduction in the tissue lipid peroxide tion. The aqueous extract has demonstrated dose-dependant invitro antioxidant property (at 20 mg, 40 mg, 60 mg, 80 mg, 100 mg) in all the models of the study. Similarly, aqueous extract of Euphorbia tirucalli at the doses of 125mg/kg and 250mg/kg produced significant hepatoprotective effect by decreasing the serum enzymes, bilirubin, cholesterol, triglycerides and tissue lipid peroxidation, while it significantly increased the levels of tissue GSH in a dose-dependant manner. From the present study, it may be concluded that the test extract possesses antioxidant and hepatoprotective properties. The hepatoprotective property may be attributed to its antioxidant potential.