According to the English literature, various lasers and light sources (i, g. argon ion lasers, pulsed KTP lasers, diode lasers and Nd: YAG lasers, pulsed dye laser (PDL), intense pulsed light sources (IPLS) are applicable for the treatment of different vascular lesions. These conditions are the most important indication for laser therapy.This review summarizes the current literature on IPL with regard to the treatment of vascular lesions.

Background: Results of various studies suggest that the hypertrophic and keloid scars are highly prevalent in the general population and are irritating both physically and mentally.Objective: Considering the variety of existing therapies, intense pulsed light (IPL) method along with corticosteroid injection was evaluated in treating these scars.Materials and Methods: 86 subjects were included in this clinical trial. Eight sessions of therapeutic intervention were done with IPL along with corticosteroid intralesional injection using 450 to 1200 NM filter, Fluence 30-40 J/cm2, pulse duration of 2.1-10 ms and palsed delay 10-40 ms with an interval of three weeks. To specify the recovery consequences and complication rate and to determine features of the lesion, the criteria specified in the study of Eroll and Vancouver scar scale were used.Results: The level of clinical improvement, color improvement and scar height was 89.1%, 88.8% and 89.1% respectively. The incidence of complications (1 telangiectasia case, 7 hyperpigmentation cases and 2 atrophy cases) following treatment with IPL was 11.6%. Moreover, the participants’ satisfaction with IPL method was 88.8%.Conclusions: This study revealed that a combined therapy (intralesional corticosteroid injection+IPL) increases the recovery level of hypertrophic and keloid scars. It was also demonstrated that this method had no significant side effect and patients were highly satisfied with this method.

Background: Cutaneous leishmaniasis (CL) is a common parasitic disorder that is endemic in many countries. There is no completely effective treatment for this condition, but pentavalent antimony compounds are regarded as the main treatment. Different laser types have been used for treatment of CL with variable success but to our best knowledge, there is no published paper regarding use of intense pulsed light (IPL) for treatment of CL. Materials and Methods: In this randomized, single-blind clinical trial study, we compared the efficacy of intralesional glucantime alone versus intralesional glucantime plus weekly IPL for treatment of 54 patients with confirmed cutaneous leishmaniasis for a maximum of eight weeks as a randomized, clinical trial. Results: Although it was not statistically significant, combination treatment was more effective than intralesional glucantime alone (P > 0. 05). However, the velocity of healing was significantly higher in the IPL plus intralesional glucantime alone versus glucantime alone. No side effect was observed in both groups. Discussion: To better evaluate the efficacy of IPL, more studies with a higher number of patients and using various IPL filters are recommended.

Background: Keratosis rubra pilaris is a common condition with an estimated percentage of 40% involvement in the population. This condition is inherited as an autosomal dominant trait and more commonly involves patients with dry skin. In the current study, we evaluated the efficacy of intense pulsed light (IPL) plus ammonium lactate versus ammonium lactate alone in the treatment of keratosis pilaris. Methods: A total of 50 patches were selected in 10 patients. If there were two similar patches with the same color and same location, each of them was randomized to receive ammonium lactate (Kerapil cream® ) or ammonium lactate (Kerapil cream® ) +IPL. Treatment was performed for 3 months, and improvement was rated by physicians and patients one month and two months after the intervention. Results: The grade of improvement in the IPL + ammonium lactate was not significantly higher than ammonium lactate alone group as rated by blinded physicians at week 4 (P > 0. 05). However, the score of improvement was also higher, as rated by the patients, in the IPL + ammonium lactate versus ammonium lactate alone (P < 0. 05) at week 8. Conclusion: Our results demonstrated that addition of IPL to ammonium lactate could improve the clinical response of keratosis pilaris lesions.

Introduction: Intense pulsed light (IPL) has long been used for skin rejuvenation.Photo rejuvenation with red light (with or without photo sensitizer) is a newer noninvasive way for this purpose; but, until now few comparative studies between these modalities have been performed. The aim of this study was comparing efficacy, adverse effects, and compliance of intense pulsed light rejuvenation and red light photo rejuvenation in a homogeneous group of women.Methods: In this clinical trial, ten female volunteers with Fitzpatrick skin type I, II, and III were enrolled. Patients underwent 6 sessions of IPL rejuvenation at 4-week intervals on one side, and 30 photo rejuvenation session (2 times a week) with red light on the other side of their face. Improvement of the skin texture and reduction in the wrinkles were determined in two ways. Firstly, by comparing the photographs, and secondly, by measuring the skin elasticity with Reviscometer MPA 9 system, before and after the procedure.Results: Both treatments were associated with improvement in the skin texture and wrinkle depth, but red light was more effective on the nasolabial fold and IPL was more effective on the fine wrinkles.Conclusions: Red light photo rejuvenation without the use of photosensitizer can be a new, effective and safe procedure for rejuvenation.