Background and Objectives: One of the indicators of mental health is life satisfaction, and the individual's attitude toward life satisfaction is the general assessment of the whole of his life or some aspects of life such as family life and educational experience. The aim of this study was to determine the relationship between emotional Intelligence, successful Intelligence, moral Intelligence, and cultural Intelligence, and life satisfaction with mental health mediation. Materials and Methods: This descriptive-correlational study was a path analysis. The statistical population consisted of all students of Tonekabon Azad University in the academic year 2019-2020 who were selected by non-random sampling method and available to 200 students. Data were collected using a life satisfaction scale, unaffiliated culture Intelligence test, emotional Intelligence test, successful Intelligence questionnaire, moral Intelligence questionnaire, cultural Intelligence questionnaire, and general health questionnaire. Data analysis was performed using SPSS and AMOS software using path analysis method. Results: The mean (SD) age of male students was 27. 7 (6. 9), and female students were 25. 8 (6. 5) years. With increasing emotional Intelligence with an average (SD) of 3. 0 (0. 4), moral Intelligence with an average (SD) (0. 5) 3. 9, successful Intelligence with mean (SD) (0. 5) 6. 6, cultural Intelligence increased with an mean (SD) of 2. 6 (0. 6), life satisfaction with mean (SD) 1. 0 (0. 6) (P<0. 01). With the increase of emotional Intelligence, moral Intelligence, successful Intelligence, and cultural Intelligence, mental health improved with a mean (SD) of 2. 9 (0. 5), where lower scores of mental health meant higher mental health level, (P<0. 01). Also, with increasing mental health, life satisfaction decreased (low scores in mental health mean higher mental health) (P<0. 01). Mental health has a mediating role in the relationship between emotional Intelligence, moral Intelligence, successful Intelligence, and cultural Intelligence with life satisfaction (P<0. 01). Conclusion: The study showed that with increasing emotional Intelligence, moral Intelligence, successful Intelligence, and cultural Intelligence, life satisfaction increased. With increasing emotional Intelligence, moral Intelligence, successful Intelligence, and cultural Intelligence, mental health status improved. Also, life satisfaction decreased with increasing mental health. Mental health played a mediating role in the relationship between emotional Intelligence, moral Intelligence, successful Intelligence, and cultural Intelligence and life satisfaction. Life satisfaction increased with the direct effect of emotional Intelligence, moral Intelligence, successful Intelligence, and cultural Intelligence on mental health.