Background and Objectives: Despite superior privileges that multiphase motors offer in comparison with their three-phase counterparts, in the field of multiphase linear induction motors (LIMs) few studies have been reported until now. To combine the advantages of both multiphase motors and linear induction motors, this paper concentrates on multiphase LIM drives considering the end effects. Methods: The main contributions of this paper can be divided into two major categories. First, a comparative study has been conducted about the dynamic performance of Fuzzy Logic Controller (FLC) and Genetic-PI controller for a seven-phase LIM drive; and second, because of the superior performance of the FLC method revealed from the results, the harmonic pollution of the FLC based LIM drive has been studied in the case of supplying through a five-level Cascaded H-bridge (CHB) VSI and then compared with the traditional two-level VSI fed one. Results: The five-level CHB-VSI has utilized a multiband hysteresis modulation scheme and the two-level VSI has used the traditional three-level hysteresis modulation strategy. Note that for harmonic distortion assessment both harmonic and interharmonic components are considered in THD calculations. Conclusion: The results validate the effectiveness of the proposed FLC for seven-phase LIM drive supplied with five-level CHB-VSI and guarantee for perfect control characteristics, lower maximum starting current, and significant harmonic and interharmonic reduction.

 Background: Endometriosis is a prevalent women's health disorder that lacks a definitive cure. Numerous studies have been conducted to identify the underlying causes of this disease and select the most effective pharmaceutical intervention. ISL LIM homeobox 2 (ISL2) plays a significant role in promoting angiogenesis. Contemporary investi­gations strongly suggest that inhibiting angiogenesis could lead to the modulation of endometriosis and reduce associ­ated symptoms. This study aims to repurpose drugs to target ISL2 for endometriosis treatment.Materials and Methods: In this computational study, we sought to confirm that ISL2 is an appropriate target for this study by evaluating its expression in the endometrial tissues of patients diagnosed with endometriosis, as well as in tissues from a control group of healthy women. Subsequently, we used computational techniques to select the best inhibitor for ISL2 from among select food and drug administration (FDA)-approved drugs.Results: There was a significant increase ISL2 gene expression in the tissues of women with endometriosis. Therefore, we selected the ISL2 protein as a target for drug repurposing. Initial docking results revealed that, out of 2471 FDA-approved drugs, six (Dactinomycin, Paritaprevir, Ivermectin, Ergotamine, Alectinib, and Simeprevir) exhibited the most favourable binding energy (ΔG ≤-8 kcal/mol) with ISL2. Molecular dynamics (MD) simulations of these six complexes showed that Ivermectin displayed the lowest root mean square fluctuation (RMSF) and root mean square deviation (RMSD), as well as the highest count of hydrogen bonds and number of contacts, which indicated a more stable forma­tion of this complex with ISL2.Conclusion: Although these six drugs appear to be promising candidates for modulating endometriosis, Ivermectin is more likely to effectively inhibit ISL2.

Background: This study was performed to evaluate in vitro and in vivo Leishmanicidal potential of morphine (Mph), imiquimod (IQ), and their combination. Methods: Leishmania infantum promastigote and amastigote assays were performed at the presence of 0. 015– 150μ M Mph, 0. 04– 416μ M IQ, and their combination. The inhibition effects of these drugs on promastigotes were evaluated after 24, 48, and 72h. The cytotoxic effects of the drugs were evaluated by MTT as well as flow cytometry after 72h. We explored the therapeutic effects of Mph and IQ in BALB/c mice at the end of the treatment using parasite load de-termination and cytokine assay. One group of mice received Mph for three weeks before infection. Results: The results of promastigote and amastigote assays showed the cytotoxic effects of the drugs at low concentra-tions. The cytotoxic effects were higher on promastigotes than amastigotes (p< 0. 05). There was a negative correlation between drug concentration and amastigote/promastigote viability. Imiquimod alone or combined with Mph showed remarkable cytotoxic effects at all concentrations (p< 0. 05). Flow cytometry results revealed apoptosis in the parasite following exposure to the drug combinations. Accordingly, the reduction of parasite loads in the spleen and liver was observed (p< 0. 05) with simultaneous increases in IFN-γ and IL-4. We believe that the in vivo leishmanicidal effect was mediated by Mph through IL-4 and by IQ through both IL-4 and IFN-γ . Conclusion: Results pointed out the promising effects of Mph and IQ at low concentrations, especially when combined.

Background and Objectives: Linear Induction Motors (LIMs) are favorite machines utilized in various industrial applications. But, due to the end effect phenomena, control of a LIM drive is more complicated than rotational machine drives. Therefore, selecting the proper control strategy for a LIM drive has been a significant challenge for the researchers.Methods: This paper concentrates on a new Model Predictive Control (MPC) of LIM drives which considers the end effect.Accordingly, the discrete-time model of the LIM with end effect is extracted, and the required flowchart used for the MPC of LIM drive has been presented in this paper.Results: To study the effectiveness of the suggested strategy, simulation results of a LIM drive with MPC are presented and compared to the traditional Indirect Field Oriented Control (IFOC) of LIM drive. Simulations have been carried out using Matlab. The end effect has been considered in the LIM model and control strategies.Conclusion: Simulation results validate that the suggested MPC of LIM drive yields excellent dynamic characteristics such as fast speed response with no overshoot. Moreover, in comparison to the traditional IFOC method, the suggested MPC strategy offers lower current ripple and lower electromagnetic force ripple, and therefore, it is suitable for industrial drive applications.