Background: Different electrocardiographic (ECG) results, seen in coronavirus disease 2019 (COVID-19) patients are most likely due to the combined impact of acute COVID-19 and chronic heart disease. Few studies have addressed the effects of hypoxemia, the hallmark of the pandemic disease, on ECG. Objectives: The present study discusses the prevalence of arrhythmias and disorders of conduction system in demised and survived COVID-19 patients, usingECGandSokolow-Lyonvoltage as a sign of hypoxemiato predict mortality in the admitted patientsandafter discharge. Methods: We investigated the ECG, and other medical data of 960 COVID-19 patients admitted to Faghihi hospital in Shiraz, Iran, from August 2021 to December 2021. Results: Most of the patients were male (541 or 56. 4%) and older than 65 years old (462 or 48. 1%). A total of 475 (49. 5%) patients died. Multiple logistic regression revealed an independent association between the COVID-19 death rate and cardiovascular disease (OR = 3. 05,95% CI: 1. 96-4. 74), QT dispersion more than 40 (OR = 5. 08,95% CI: 3. 61-7. 15), heart rate (more than 100 versus less than 60 OR = 2. 86,95% CI: 1. 03-7. 9), ST segment elevation myocardial infarction (OR = 3. 93,95% CI: 2. 63-5. 86), poor progression (OR = 2. 33,95% CI: 1. 56-3. 49), hypertrophy (OR = 1. 97,95% CI: 1. 02-3. 81), and Sokolow-Lyon (OR = 2. 91,95% CI: 1. 64-5. 16). Conclusions: Electrocardiographic examination of COVID-19 patients is important during admission and after discharge. Sokolow-Lyon voltage less than 10 can be regarded as an independent predictor of mortality in COVID-19 patients discharged from hospital.