Nursing care during dialysis involves managing symptoms and preventing complications among patients undergoing hemodialysis or peritoneal dialysis. In this regard, to improve the quality of nursing care during dialysis, several approaches were developed to enhance hemodialysis adequacy and prevent complications,however, Machine learning (ML) emerged as a methodological approach for eval-uating hemodialysis adequacy and complications. The current study aims to analyze ML approach in predicting and managing hemo-dialysis by R programming language analysis to provide a therapeutic concept for hemodialysis management in critical nursing care. An R programming language was used to perform the logical analysis of the data. ML algorithms based on usage rate included logistic regression (LR), Support Vector Machine (SVM), Extreme Gradient Boosting (XGBoost), Random Forest (RF), Complement Naive Bayes (CNB), Takagi-Sugeno-Kang fuzzy system (G-TSK-FS), k-nearest neighbors' classifier (KNN), Stochastic gradient descent (SGD), Linear Discriminant Analysis (LDA), and Multi-adaptive neural-fuzzy system (MANFIS). Also, the use of ML in nursing care during hemodialysis is categorized into three indications for predicting hemodialysis adequacy, complications, and vascular access performance. Using ML in hemodialysis nursing care is a growing research interest. The main application areas are the prediction of hemodialysis adequacy, complications, and vascular access performance. LR and SVM are practical ML algorithms for constructing AI tools to improve hemodialysis management.