Background: In this study, an attempt was made to validate the use of OSI as a measure of ovarian response during IVF treatment and to correlate OSI with age and BMI and other measures of ovarian response such as AMH, antral follicle count (AFC), total dose of administered gonadotrophins, and duration of stimulation. Methods: This study was a retrospective comparative cohort one. The study included a total of 2150 women who underwent the first IVF cycle between January 2008 and December 2017 at our center using long-agonist protocol. Patients were divided into four subgroups according to the circulating AMH level: below the 25th percentile (AMH 0. 25-1. 1 ng/ml, subgroup A), between 25th and 50th percentiles (AMH 1. 2-1. 6 ng/ml, subgroup B), between the 50th and 75th percentiles (AMH1. 7-2. 6 ng/ml, subgroup C), and above the 75th percentile (AMH 2. 7-8. 5 ng/ml, subgroup D). Qual-itative data were analyzed by Chi-square or Fisher’ s exact test. The p<0. 05 was con-sidered statistically significant. Results: The four subgroups formed on the basis of the AMH level did not signifi-cantly differ for age, BMI and infertility duration. OSI was significantly correlated to age (r=0. 167; p=0. 001), and has negative correlation with AFC (r=-0. 236, p=0. 001) and AMH levels (r=-0. 123, p=0. 001). Multiple linear regression analysis was done on OSI with other independent variables such as age, BMI, AFC, AMH. Analysis showed that approximately 8% variation in the value of OSI can be attributed to these variables with the highest correlation with antral follicle count. Conclusion: The present study showed that OSI appears to be a highly reliable index of ovarian responsiveness to recombinant FSH and can be useful to estimate the FSH dose.

The worldwide lethal prevalence of atherosclerotic diseases has made it a crucial topic of research, the descending aorta is a major artery with complex geometry involving curvature, branches, and bifurcation leading to common iliac arteries. This paper aims to scrutinize the intricate blood flow patterns and the flow parameters with the increasing degree of stenOSIs in the infrarenal aorta, which has been accomplished through computational fluid dynamics modeling. A 3D CAD model of the healthy aortoiliac bifurcation was constructed from MR images, and three diseased models with 32%, 47%, and 71% occlusion in the infrarenal aorta region were constructed. At the inlet, pulsatile velocity and at the outlet pressure boundary conditions were applied, blood was considered Newtonian and turbulence was modeled using Large Eddy Simulation (LES). The numerical simulation was carried out using finite volume method on ANSYS. The predicted hemodynamic parameters like velocity, wall shear stress (WSS), oscillating shear index (OSI), Q-Criterion and turbulence intensity were post-processed for all the models, the analysis of which provides an insight into the myriad processes involved in the inception and evolution of atherosclerOSIs. The transition of blood flow from laminar to turbulent with increase in the degree of stenOSIs is a very eminent feature of this study, turbulence is identified in cases with 47%, and 71% occlusion and is dominant in the latter.

Oxygenation index (OI) based on arterial blood gas (ABG) test is an invasive procedure and requires indwelling arterial lines. However, the oxygen saturation index (OSI) assessed by the pulse oximetry method is simple and noninvasive for monitoring oxygenation saturation in newborn neonates with chronic lung disease. This study aimed to evaluate and compare OI and OSI among neonates in NICU who underwent mechanical ventilation. A cross-sectional study was carried out among fifty neonates (term and preterm) who were admitted to the NICU of Abuzar Hospital in Ahvaz, Iran. All neonates were examined by both ABG and pulse oximetry methods. Approximately 2 cc of arterial blood sample was taken and sent to the laboratory to determine blood gases. At the same time, the level of peripheral capillary oxygen saturation (SpO) was recorded using a pulse oximeter. OI and OSI were calculated according to their formula. Spearman’ s correlation, linear regression, and Bland-Altman scatter plot were used to determine the correlation, association, and agreement between OI and OSI, respectively. Of the total 50 neonates, 26 were female. The mean (range) gestational age was 35. 28± 3. 01 (28-39) weeks, and post-neonatal age was 6. 05± 7. 04 (1-25) weeks. There was a linear and significant association and correlation between OI and oxygen OSI (P<0. 001), while the Bland-Altman scatter plot confirmed the agreement between them in mean values. Therefore, OSI utilizing pulse oximetry as a noninvasive method can be a substitute for OI in neonates with respiratory failure. It can also reduce workloads and costs.

Background: Oxidative stress is commonly accrued in thyroid tissue during hormone synthesis. Objectives: We aimed to examine oxidative stress in patients with thyroid cancer, benign thyroid nodules, and healthy individuals. Methods: In this study, 138 individuals were involved. Among the selected participants, 108 had thyroid nodules, including 30 papillary thyroid cancer (PTC), 30 follicular thyroid cancer (FTC), six anaplastic thyroid cancer (ATC), 12 medullary thyroid cancer (MTC), and 30 benign nodules. In addition, 30 individuals were selected as a healthy control group. The levels of total antioxidant capacity (TAC) and total oxidant status (TOS) of thyroid tissue were measured using the ELISA method, and the oxidative stress index (OSI) was calculated. Results: The TAC level was signifi cantly lower in MTC and FTC subtypes than in controls. The TOS level was considerably higher in the MTC group than in the control and benign nodule groups. The TOS level was not changed in other groups. The OSI was considerably higher in MTC and FTC subtypes. The TAC and OSI in benign nodules were signifi cantly lower and higher than those of controls, respectively. The OSI was higher in female patients than in males. Conclusions: The OSI can not be considered a diagnostic biomarker for benign nodules and MTC. The diverse oxidative stress status between genders may be related to the elevated cancer incidence in females.

The Oxygenation Index (OI= [MAP×FiO2]/PaO2×100), an invasive diagnostic criterion, is routinely used as a marker of severity of acute respiratory distress syndrome (ARDS). In order to determine of OI, arterial blood gas (ABG) through an invasive procedure is indispensably used to obtain PaO2. The Oxygenation saturation Index (OSI= [MAP×FiO2]/ SPO2 ×100), as an alternative method, can be implemented using pulse oximetry to assess SpO2. For this epidemiologic-analytic study, 74 intubated patients admitted in a pediatric intensive care unit of Abouzar hospital of Ahvaz during the first 3-day admission were selected equally in pulmonary and non-pulmonary groups within a six months period, from January 1, 2019, to May 31, 2019. Two indexes of OI and OSI in both patients were evaluated, and eventually, the results were analyzed by linear regression using Spss. A comparison of the two OI and OSI indexes showed a meaningful relationship was found (P<0. 001), which has a higher correlation coefficient of 0. 726 in patients with the pulmonary disease than non-pulmonary patients with 0. 394. The present study demonstrates that the index of oxygen saturation (OSI) with a sensitivity of 78% and specificity of 83% in the patients without acute pulmonary distress syndrome is a suitable indicator instead of the invasive index of OI. Also, in patients with pulmonary disease that meet the medium range of Berlin criteria, with a sensitivity of 100% and specificity of 76%, the OSI index can be used to predict the status of patients.