Due to the recent Outbreak of norovirus in the northern area of Tehran, this report reviews the recent advances and provides guidelines for Outbreak management and disease prevention for medical practitioners. Norovirus is the most common cause of epidemic gastroenteritis, responsible for at least 50% of all gastroenteritis Outbreaks worldwide, and a major cause of foodborne illnesses. In the United States, approximately 21 million illnesses attributable to norovirus are estimated to occur annually. Since 2001, when the most recent norovirus recommendations were published (1), substantial advances have been made in norovirus epidemiology, immunology, diagnostic methods, and infection control. As molecular diagnostic techniques have improved and become more widely available, detection and reporting of norovirus Outbreaks have increased. Although the inability to culture human noroviruses in vitro has hampered the progression, assessment of the performance of disinfectants has been facilitated by the discovery of new, cultivable surrogates for human noroviruses. In addition, the periodic emergences of epidemic strains (from genogroup II type 4, GII.4) as well as Outbreaks in specific populations (e.g. the elderly in nursing homes) have been characterized (1).