PCOS is a syndrome recognized from half a century, but still there are many points unclear in its clinics and management. What to do with PCOS in adolescence? When does PCOS pathophysiology start? Can we prevent it from childhood or it goes back to the intrauterine life? What is the best way to subside insulin resistance? Where and when is the place of drug therapy to reduce insulin resistance? Is it not better to start with diet and exercise instead of using drugs? Which diet is better? How can we treat the infertility? Which kind of treatment for the ovulation induction is more effective? What to do to prevent metabolic syndrome? What's the place of life style in metabolic syndrome?