Aims: The Postpartum period presents significant physical, emotional, and social challenges for mothers. One common issue is Postpartum blues, which can negatively impact maternal well-being. This study aimed to analyze the effect of yoga exercises on preventing Postpartum blues in Postpartum mothers using family health media as an intervention. Instrument & Methods: This quantitative analytical study with a quasi-experimental approach was conducted on Postpartum mothers at the Alisah Clinic, utilizing a total population sampling technique. Data were collected through structured questionnaires and interviews and then analyzed statistically using SEM-PLS to evaluate the relationship between the frequency and duration of yoga practice, family support, and Postpartum blues prevention. Findings: The yoga exercises significantly reduced Postpartum blues symptoms. A higher frequency and longer duration of yoga sessions contributed to better mental and physical well-being. Additionally, the quality of family health media played a crucial role in enhancing knowledge and promoting behavioral changes that support yoga practice. Family support was found to positively influence the consistency of yoga practice. Conclusion: Yoga exercises, when practiced regularly with adequate duration and supported by quality health media and family involvement, are effective in preventing Postpartum blues.