SMALL MOLECULES AND ANTIBODIES HAVE REVOLUTIONIZED THE TREATMENT OF CANCER AND APPEAR PROMISING FOR THE TREATMENT OF MANY OTHER DISEASES SUCH AS NEUROGENETIC DISORDERS AS WELL. NONETHELESS, THERE ARE MANY CANDIDATE THERAPEUTIC TARGETS THAT ARE NOT AMENABLE TO ATTACK BY THE CURRENT GENERATION OF TARGETED THERAPIES AND, IN A SMALL BUT GROWING NUMBER OF PATIENTS; RESISTANCE TO INITIALLY SUCCESSFUL TARGETED TREATMENTS EVOLVES...