Background: Few studies have investigated pancreatic cancer in Tunisia and there are no reported survival data. The aim of this study was to analyze the epidemiologic profile, treatment modalities, and survival and prognostic factors of patients with pancreatic cancer in Tunisia. Method: In this retrospective study, we included patients treated between 2001 and 2016 for a histologically proven pancreatic cancer in the Department of Medical Oncology in Tunisia. Results: We examined 130 patients with a median age of 58. 7 years and a sex ratio of 1. 8. Thirty percent had surgery for a localized disease. Among resected patients, 14% received adjuvant chemotherapy. 14. 5% of the patients with borderline resectable tumors underwent induction chemotherapy without leading to surgery. Palliative chemotherapy was administrated for unresectable locally advanced (14%) and metastatic (41. 5%) tumors. Median overall survival for localized, locally advanced, and metastatic disease was 20. 5, 10. 4, and 6. 3 months, respectively. Independent prognostic factors were female gender, performance status, tumor localization, and chemotherapy. Conclusions: Unlike what was published in the literature, patients in our study were younger and there was a male predominance. Survival rates were low even for localized stages. Treatment strategy, chemotherapy protocols, survival, and prognostic factors were in line with the literature.

Ruta species are known as a potential source of natural products with biological activities. They are used in several fields such as in therapeutic and traditional medicine. In order to contribuate to the valorization of these plants, this work investigated the chemical composition and antibacterial activity of the essential oils of Ruta montana and Ruta gravelons growing in Tunisia (north of Tunisia). The total phenolic content of these two essential oils was also studied. The antibacterial activities of essential oils were assessed against Escherichia coli (ATCC7625), Staphylococcus aureus (ATCC76110), Pseudomonas aeruginosa (ATCC 7624), Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, and Pseudomonas aeruginosa. Results show that the chemical composition of essential oils was dominated by 2-undecanone (86. 77%), followed by 2-decanone (4. 91%) and 2-nonanone (23. 62%). Furthermore, the total phenolic content in essential oil of Ruta gravelons is more important than the total phenolic content in essential oil of Ruta montana. Indeed, the value of total phenolic content is 41. 70 mg Gallic acid equivalents per gram of dry extract, in essential oil of Ruta gravelons but the total phenolic content in essential oil of Ruta montana is a 7. 50 mg Gallic acid equivalents per gram of dry extract. Besides, the ruta montana essential oil has the most important antibacterial activity than the Ruta gravelons essential oil especially against Staphylococcus aureus (ATCC76110) and Pseudomonas aeruginosa (ATCC 7624).

This study empirically investigates the relationship between the timeliness of the financial reporting and the corporate governance proxies for companies listed on the Tunisian stock exchange during 2009. It investigates the role of the corporate governance mechanisms on the timeliness of corporate financial reporting besides, it investigates the relationship between the company size, leverage, profitability (good news), and the timeliness of corporate financial reporting. Using a multivariate analysis, we find evidence that ownership concentration, the CEO's duality function, and good news have some impact on the interim period between the auditors’ signature dates and the publication dates, hence, on the timeliness of the release of financial statement information to the public.