ABSTRACT The attention of contemporary planners to environmental factors and increasing awareness and communication of man with his surrounding environment has increased the layers and defining factors of design and planning concepts. In such a way, a common problem with the issue of environmental capabilities to respond was put in front of the planners. The collection of ideas presented in this era was in the form of responsive planning, focusing on the maximum use of environmental capabilities. The necessity of the emergence of a comprehensive discourse to overcome the plurality of factors, definitions and design methods in the environmental fields has been given less attention. Based on this, the current research aims to organize the leading theories in this field in a targeted manner and seeks to improve them based on their synergy. The structural question of this research is the meanings, examples and meaningful contexts of flexibility in various aspects and scales of urban planning. The research method used is qualitative thematic analysis with the help of artificial intelligence in MAXQDA software in a 6-step processing process. The important application of this research is to structure the minds of the planners of this field to reduce the scattered and interdisciplinary problems of the resources. The results of this research revealed dimensions such as identification and recognizability, diversity and changeability, adaptability and expandability, distribution, separation and continuity, organization and compatibility in the field of flexibility and related to the corresponding parts in urban planning   Extended Abstract Introduction Responsiveness-based design and planning emphasizing the maximum use of environmental capacities to meet users' needs implicitly cause a targeted improvement of environmental quality. As the environmental awareness of contemporary man has expanded and the platforms have become more diverse, many challenges are raised in the field of environment-oriented in the field of infrastructure quality and service provision. Urban developments and new developments in cities should be interpreted with integrated conceptualization. The conceptualization of interpretive flexibility in the planning and designing of public spaces in the city is used as an interdisciplinary perspective in urban space design to open and discuss its connection and potential as an approach to strengthening social cohesion and inclusion. The general definition of flexibility is that it can create places with new forms of meaning and be used for different groups to strengthen its coherence and multidisciplinary inclusion in terms of design and planning of space and body. On this basis, the concept of flexibility is proposed as a principle in the context of design and planning due to its wide range of effects on background phenomena. The history of such a role can be seen in the diversity of users' needs. In such a way, it is impossible to express the specific time and area of the need to pay attention to this concept. This is in line with Oldenburg's theory of "social public spaces," in which being in public space, communicating with people and the environment through observing the streets, sidewalks, squares, and parks of the city is a necessary step for people as a part of their social life. The meaningfulness of the design of the artificial environment was considered. In any case, in the contemporary era, on the one hand, at the same time as the quantitative and qualitative increase of human environmental awareness, there is no longer any phenomenon in the eyes of contemporary man arising from a unique aspect and range of factors. On the other hand, his life needs in the individual and collective dimensions have seen a high diversity, which has led to the formation of multiple semantic domains of past flexibility. The meaning of flexibility in such an interdisciplinary platform and basic design refers to the concept of understanding and responding quickly and efficiently to environmental changes. Such a holistic definition for this broad field of environmental design means the implicit acceptance of the role of scale in the meaningful domain of these concepts. On a macro scale, it means making design options to increase the presence, participation, and power of choices of users of the environment in participatory urban planning and design methods, and on a small scale, it means making design options to increase spatial quality and, as a result, the quality of activities. The daily activities of environmental users are through selection against the "dominant space." flexibility at different scales is crucial for dimensional optimization, shaping, and structuring spatial features, leading to improved performance of space components and spaces. The development of the concept of "flexibility" from various studies in metropolitan to micro scales, such as interior architecture, allows it to pass the discourse of responsiveness to provide a broad approach to environmental design in which different values, interests, and priorities are prioritized. As a result, the issue of flexibility in environmental design has been raised as a multi-dimensional field in the design and planning of the basic environment. The breadth and complexity of this concept have made the researchers of this field deal with it in one or more ways, and it has been avoided to provide a comprehensive framework about the nature and structuring processes. The current research presents a structured view of flexibility in architecture and urban planning with an environmental approach.   Methodology The methodology to achieve this goal is to use the macro research method and achieve a comprehensive framework by combining categorized interpretations. In such a way that by sorting and categorizing these concepts and bases in a new way, he has found a new level of theoretical findings, which will be a suitable answer for the gaps in scientific knowledge and scientific methods created in this field. In this context, the research method "thematic analysis" has been used with a qualitative approach and the use of library resources. Also, to overcome the breadth and complexity of these concepts and the multi-layer networking of concepts in this research method, artificial intelligence has been used in MAXQDA research assistance software.   Results and discussion In the meantime, attention should also be paid to the fields of influence and application of the results of this research because designers refer to flexibility as the creator of environmental qualities, including dynamism. Also, since flexibility, along with the principles of readability and adaptability, affect the lifestyle and behavioral patterns of the audience of environmental design in architecture and urban planning, it will also be effective in dealing with the challenge of complexity in environmental design factors. One of the key questions for achieving research goals on this issue is how flexibility in environmental design impacts the relationship between flexibility and scale.   Conclusion The most important finding of this research suggests that first, it requires a focus on the conditions under which the processes of perceiving human abilities and discovering the needs of the human audience can manifest. The theoretical framework arises from a comparative approach between design disciplines. These conditions are independent of the final state of the design product, and strengthening the environmental capacities will lead to a direction and an area that includes environmental flexibility. By responding to new situations, the construction of the space and the body within a space building can be adapted to various configurations. Even though the environment may remain constant, the designed place will continue functioning as a strong living system over time.  It also seems that the nature of issues related to flexibility has complexity. Considering that the quality of flexibility in urban planning and architecture is significant in multilevel and multifaceted scales from micro to macro, it is important to pay attention to the scale of different variables. In order to reduce this problem, the consistency and adjustment of the scale of the variables measured in a specific analysis should be considered in the first step.   Funding There is no funding support.   Authors’ Contribution All of the authors approved the content of the manuscript and agreed on all aspects of the work.   Conflict of Interest Authors declared no conflict of interest.   Acknowledgments We are grateful to all the scientific.

Probability density functions of the involved random variables are essential for the reliability-based design of offshore structures. The objective of present research was the derivation of probability density function (PDF) for the local joint flexibility (LJF) factor, fLJF, in two-planar tubular DK-joints commonly found in jacket-type offshore structures. A total of 162 finite element (FE) analyses were carried out on 81 FE models of DK-joints subjected to two types of axial loading. Generated FE models were validated using available experimental data, FE results, and design formulas. Based on the results of parametric FE study, a sample database was prepared for the fLJF values and density histograms were generated for respective samples based on the Freedman-Diaconis rule. Nine theoretical PDFs were fitted to the developed histograms and the maximum likelihood (ML) method was applied to evaluate the parameters of fitted PDFs. In each case, the Kolmogorov-Smirnov and chi-squared tests were used to evaluate the goodness of fit. Finally, the Inverse Gaussian model was proposed as the governing probability distribution function for the fLJF. After substituting the values of estimated parameters, two fully defined PDFs were presented for the fLJF in tubular DK-joints subjected to two types of axial loading.

Contracts can be set in one of the two following ways: rigid or flexible. The first type focuses to foresee all the rights and obligations of both of the parties only through attaching importance to legal relations. The drawback of such contracts is their lack of adaptability with the possible future changes in the conditions which can lead to loosing opportunities. On the other hand, flexible contracts, especially used in long-term business relations, are adaptive to possible future changes as they establish balance among interpersonal, legal, and exchange relations. flexibility is a beneficial skill that can be used when changes arise. According to surveys rigid contracts were favored in the past while flexible ones, due to their ability to keep pace with an accelerated world, are popular today. By its descriptive-analytic approach, the present research attempts to introduce flexible contracts and their benefits, and also the ways through which it is possible to make contracts flexible and keep their stability at the same time under the two headings of collaboration and visualisation.

Deciding on the financing and composition of capital structure in Corporates depends on a variety of factors. Several studies have shown that financial flexibility is the most important factor affecting capital structure and corporate financing decisions. The main objective of the research is to measure the financial flexibility of Corporates accepted in Tehran Securities Exchange (in accordance with the corporate environment and conditions). Therefore, according to the purpose of the research, in the first Step, based on the conceptual and theoretical framework derived from the exploration and exploration in specialized texts, the views of financial experts (including university professors and market experts) in order to understand their views and identify the dimensions, components, indexes and factors determining the financial flexibility of the Corporates were obtained through a questionnaire. In the second step, after referring to the model, the correlation method as one of the subsections of the descriptive research methodology for measuring the components of cash holdings, debt capacity, and capital market measure of Tehran Securities Exchange Corporates with the actual and historical information of financial statements and information Corporate stock trading (through multivariate regression tests and confirmatory factor analysis) The results of the measurement of the three components indicate that the amount of cash holdings, the size of the debt capability, and the relatively downward trend of the size of the capital market (stock liquidity) of the Tehran Securities Exchange corporations during the years 1380 to 1394, are. Measuring the dual dimension of financial flexibility also implies the use of internal financial flexibility and the non-use of external financial flexibility. Which can be explained by Trade off Theory, Pecking Order Theory and of asymmetric information Theory.

In this study, different approaches including addition of disulfide bridges, saturation of surface charges, and decrease of segmental flexibility have been used to increase thermostability of firefly luciferase. A disulfide bridge is introduced into Photinus pyralis firefly luciferase to make two separate mutant enzymes. One of the designed mutant (A103C/S121C) showed remarkable thermal stability, its specific activity decreased, whereas the A296C/A326C mutant showed tremendous thermal stability and 7.3-fold increase of specific activity. Analysis of enzyme according to residues B-factors shows that its C-terminal is much more flexible than its N-terminal. Two mutations in the most flexible region of luciferase were designed. Analysis shows that D476N mutation doesn' t have any significant effect but D474K mutation destabilized protein. On the other hand, flexibility analysis using dynamic quenching and limited proteolysis demonstrates that D474K mutation became more flexible than wild type. Protein engineering studies have shown that thermostable proteins have a higher frequency of Arg, especially in exposed states. To further elucidate the arginine saturation effects on stability of firefly luciferase, some of hydrophobic solvent-exposed residues in luciferase are changed to arginine. All of these residues are located at the external loops of L. turkestanicus luciferase.Introduction of double mutation (-Q35R/I232R) and triple mutation (- Q35R/I232R/I182R) were reserved specific activity of enzyme while its stability was enlarged and its flexibility was declined. Structural and functional properties of the mutants were investigated using different spectroscopic methods. It seems a clear relationship between stability and segmental flexibility in firefly luciferase controls its activity under different conditions.