Methods: Based on inclusion and exclusion criteria, 20 patients primarily diagnosed with CUPAx referred to our breast multidisciplinary team (MDT) sessions between July 2010 and December 2016 were evaluated. The patients were categorized into three groups based on the types of treatment: mastectomy and radiation therapy, radiation therapy, and observation group. Conclusion: The result suggested that mastectomy was effective in lowering the risk of disease progression in Iranian women diagnosed with CUPAx and highly suspicious breast origin. More studies on larger sample groups are needed. Background: Cancer of unknown primary involving axillary lymph nodes (CUPAx) is a very rare type of cancer. There are still many challenges about the management and outcome of the disease. This retrospective study is an attempt to assess the overall survival and the outcome of CUPAx in Iranian women. Results: The mean age of the subjects was 52 ± 7. 91 years (range: 42-74). The results manifested significant differences between the outcomes of three types of treatments. The patients who received both mastectomy and radiotherapy had a higher survival rate and no sign of the disease compared with other groups (P= 0. 03). The median survival time in the mastectomy group was 78 months and 23 months for the group with no mastectomy (95% CI: 7. 64-38. 36) (P <0. 001).

Smart applications with interconnected intelligent devices for sharing services arise serious security problems to the stability of this IoT complex and heterogeneous environment. Unless security considerations are analyzed and implemented properly in real time then IoT cannot be perceived as a pervasive network for the possible stakeholders. Current state of the art has analyzed trust-based security solutions as additional feature to application layer of the system which can identify and filter out the malicious nodes. In this paper we are proposing holistic trust management with edge computing mechanism to create trustworthy zones comprising different clusters, where Gateway on behalf of clusters will initiate migration of their nodes if falls below the defined Zone trust threshold level. The created zones are self-resilient against any malicious attacks and saves lots processing usage time and energy to address the security issues. By analyzing our proposed algorithm with other contemporary approaches to handle IoT security issues using trust mechanism, this approach is more precise in terms of protecting system against incurring malicious behavior, and also prolong the application operation duration by reducing communication and processing overhead.