Melamine nephrotoxi city as a result of consumption of tainted milk products in China has recently become an important topic in pediatric nephrology.1 The reported cases of acute kidney failure due to the melamine intoxication is the present focus.1 Recently, the BMJ published an interesting paper on the screening for proteinuria in the children after exposure to low-dose melamine and the conclusion that “Urgent and large scale renal screening in children with a history of exposure to low dose melamine may not be necessary,” and 1% to 2% of proteinuria rate was reported.2 By nature, melamine can mimic a protein and can cause false positivity in quantitative determination of protein level in milk.1 This can raise the question whether melamine can cause false positive results for protein in vivo. Here, the author tried to use basic biochemeoinformatics principles to support the observation that there is a very low rate of proteinuria in the children after exposure to lowdose melamine.