THREE COAGULATION RELATED MUTATIONS AND INCREASED RISK OF MYOMA IN WOMEN OF FARS PROVINCE

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MOGHTADERI NASAB RAZIEH

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Journal: Zahedan Journal of Research in Medical Sciences Year:2016 | Volume:18 | Issue:10 Page(s): 0-0

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Title

THREE COAGULATION RELATED MUTATIONS AND INCREASED RISK OF MYOMA IN WOMEN OF FARS PROVINCE

Author(s)

MOGHTADERI NASAB RAZIEH | Issue Writer Certificate

Keywords

UTERINE MYOMAQ4

MTHFRQ4

EPCRQ4

POLYMORPHISMQ4

Abstract

Background: Myoma is one of the most common benign tumor in the women’s genital tract and causing some implications such as miscarriages, anemia or even infertility. Since tumorigenesis is associated with a hypercoagulant state, we investigate the role of coagulation related variations in methylene-tetra hydrofolate reductase (MTHFR) and endothelial protein C receptor (EPCR) genes in patients with UTERINE MYOMA.Methods: In this case- control study, genotyping was performed for rs867186, rs1801131 and rs1801133 by amplification-refractory mutation system- polymerase chain reaction (ARMS-PCR) method in 73 patients withmyoma and 73 healthy women. Data was analyzed by logistic regression and2 test through software SPSS 16.Results: A statistically significant difference was observed between patients and the control group regarding the frequency of allele C in the MTHFR (A1298C) gene (P=0.01). The frequency of the genotypes carries at least one C allele (CC+AC) is higher in patients (13.7%) compared to controls (2.7%). This means the C allele increases the risk of the disease (P=0.01). Although the frequency of the T allele in patients was higher than controls, no significant relationship was observed between it and the risk of the disease. Our studied population was completely homogeneous for allele A at EPCR locus.Conclusions: In conclusion, results revealed a significant association between A1298T variation and myoma incidence, but more research is needed to verify the role of this mutation as a genetic marker in UTERINE MYOMA.

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APA: Copy

MOGHTADERI NASAB, RAZIEH. (2016). THREE COAGULATION RELATED MUTATIONS AND INCREASED RISK OF MYOMA IN WOMEN OF FARS PROVINCE. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 18(10), 0-0. SID. https://sid.ir/paper/356542/en

Vancouver: Copy

MOGHTADERI NASAB RAZIEH. THREE COAGULATION RELATED MUTATIONS AND INCREASED RISK OF MYOMA IN WOMEN OF FARS PROVINCE. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2016;18(10):0-0. Available from: https://sid.ir/paper/356542/en

IEEE: Copy

RAZIEH MOGHTADERI NASAB, “THREE COAGULATION RELATED MUTATIONS AND INCREASED RISK OF MYOMA IN WOMEN OF FARS PROVINCE,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 18, no. 10, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/356542/en

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