Background: Carpal tunnel syndrome is an important cause of pain and functional impairement of the hand due to compression of the median nerve at wrist. About 0.5% of the general population affected. About 3% of adults have symptomatic electiodiagnostically confirmed corpal tunnel syndrome. In patients whose condition fails conservative treatment, surgical division of the transverse carpal ligament, either by an open or endoscopic procedure, promptly improves or relieves sensory complaints 75% to 99% of the time.Materials and Methods: Between 1997 and 1999, 63 patients with surgical treatment for carpal tunnel syndrome were studied in Rasht Poorsina hospital. The diagnosis of carpal tunnel syndrome confirmed clinical and electrodiagnostic. Pain, tingling, burning, numbness or some combination of these symptoms on the palmar aspect of the thumb, index and middle fingers, and radial half as tinel's sign, Phalen's maneuver, etc were clinical characteristics.Neurophysiological confirmation required a distal median motor latency of >4.6 ms combined with a median sensory nerve action potential of <15 m V After preparating of patients for operation, the surgeon made an incision 4-5 cm long, extending distally from the distal wrist crease, and released the transverse carpal ligament under direct visualization.Findigs: 48 patients (76.2 %) were female and 15 patients (23.8%) were male. Female to male ratio was 3.2 to 1. The maximum age was 63 years and the minimum age was 25 years. 14 (22.2%) of patients had underlying conditions: 11 (17.4%) diabetes mellitus, 2 (3.2%) rheumatologic disorders, 1 (1.6%) both diabetes mellitus and hypothyroidism.Results: Carpal tunnel syndrome is a common clinical problem with lack of an standard ideal criterion for treatment. According to our data, sever disease that required surgery, is more frequent in females but as we know, it is consistently milder in female patients than in male patients17. thus, we should explain this discrepancy. In our study, the mean age of patients was 44.81±8.67 years. The majority of subjects were active in social and occupational activities (such as worker and employee), thus decreasing age of severity in our region should be considered as an important view and this significant problem should be solved properly. A history of nocturnal symptoms has moderate sensitivity (51-77%) and specificity (27-68%). Phalen maneuver has sensitivity and specificity between 40% and 80%.Conclusion: Carpal tunnel syndrome is a common clinical problem that responds well to treatment. Because of decreasing age of patients with severe disease, primary care physicians should be aware of the different aspects of this syndrome when the patients required proper treatment, should refer them to neurologists for decision making as soon as possible, to prevent subsequent debilities especially in a younger and active patients.