The corona virus, as a pandemic disease, has exposed the world to difficult and critical conditions. In the meantime, the health service delivery system is at the forefront of confronting and controlling this crisis. Given the special circumstances of the crisis and the threat to public health in Iran, the need for creativity and innovation to manage the corona crisis is more pressing than ever. Open innovation is a phenomenon that has a significant impact on the innovation cycle, increasing research and development costs as well as scarcity of resources. By leveraging these benefits and using new ideas, we might be able to manage crises and reduce damage, especially the COVID-19 crisis. The open innovation paradigm emphasizes the success of the organization by using external and internal ideas. The basic idea behind open innovation is that there is an extensive knowledge that an organization cannot access all through its own proprietary research. So, it must leverage other research through the licensing, patenting process or purchase from other companies. In this model, organizations outsource some parts of the R&D process, use external ideas, constantly monitor the new products of competitors and leading companies, and in some cases collaborate with competitors and other research centers. 1, 2 In the process of innovation, studies show that the field of health and treatment has taken on an open nature, and partnership with external organizations has become a key factor and a vital capability. 3, 4 In this way, valuable ideas can originate from outside the organization and the process of successful activity can be achieved through partnerships with external factors. 5 Open innovation has a wide meaning in the field of health, 6 which is mentioned below: Technical and clinical innovations: New therapeutic drugs, diagnostic tests, medical devices, software, surgical techniques Process and service innovations: institutions, business models, service models, clinical pathways, roles, education System innovations: Policy innovation, reform of systems