مجله دانشگاه علوم پزشکی گرگان
سال:1400 | دوره: | شماره: |تعداد مقالات:14

Background and Objective: Multiple sclerosis (MS) is one of the most common progressive neurological diseases affecting the motor pathways leading to muscle fatigue. This study was done to evaluate the effect of eight weeks of aquatic exercises on fatigue, balance and functional training in male patients with multiple sclerosis. Methods: This clinical trial study was done on 15 men with multiple sclerosis in Zahedan, south-east of Iran. The subjects selected by available and purposeful sampling method participated in research. After primary screening and reconnaissance person of bona fide, subjects randomly divided into intervention group (n=8) with average age 42. 62±, 6. 67 height 171. 87±, 2. 47 weight 69. 62±, 12. 39 and control group (n=7) with average age 30. 28±, 7. 11, height 171. 57±, 8. 05 weight 66. 68±, 17. 26. During study the patients used and follow medicinal drugs according to prescription. Subjects in interventional group were received aquatic exercises program. Aquatic exercises program consisted of 8 weeks, 3 sessions per week. The level of fatigue, balance and functional movement respectively evaluated with fatigue assessment battery for MS, Y balance and side hop jump tests. Results: The mean of functional movement was significantly increased in interventional group in comparison with controls (P<0. 05). The mean of fatigue was significantly reduced in interventional group compared to controls (P<0. 05). Conclusion: Eight weeks of aquatic exercises improves functional movement and reduce fatigue in male patients with multiple sclerosis.

Background and Objective: Spastic diplegia cerebral palsy is a movement disorder originating from brain injury before, during, or immediately after birth. Exercise plays an important role in motor recovery. This study was performed to determine the effect of high-intensity circuit training on balance and activity daily living in children with cerebral palsy (CP). Methods: In this clinical trial, 34 children with cerebral palsy were randomly divided into two groups of 17 including occupational therapy (control group) and circuit training group with occupational therapy as interventional group. Berg balance scale and activity scale for kids were used to assess changes in balance and activity of daily living before and after 12 weeks of exercise, respectively. High-intensity circuit training consisting of 3 rounds and each round consisting of 6, 30-second stations and a 30-second break between stations, which were performed three times a week for 12 weeks. Occupational therapy was performed one session per week. Results: The rate of balance and activities of daily living and its components in the circuit training group with occupational therapy showed a significant improvement compared to control group (P<0. 05). Conclusion: Circuit trainings with occupational therapy can further improve the performance of balance and activity of daily living in children with Spastic diplegia cerebral palsy compared to occupational therapy.

Background and Objective: Physical activity and the use of herbal supplements can affect liver enzymes. Nano-curcumin is an effective ingredient (deferulovl methane) in turmeric with antioxidant, antibacterial, antifungal, antiviral, antiinflammatory and anti-proliferative properties and can play an important role in preventing liver fibrosis. This study was performed to determine the effect of 6 weeks of high intensity interval training (HIIT) with Nano-curcumin supplementation on liver enzyme levels in overweight female students. Methods: This clinical trial study was performed on 48 overweight female students of Shahid Chamran University of Ahvaz, Iran with an average age of 21. 7±, 1. 32 years and a BMI equals 27. 8±, 2. 46kg/m 2 during 2018. Participants were randomly divided into 4 groups: control, Nano-curcumin supplementation (One 80 mg capsule daily), training and training combined with nano-curcumin supplementation (one 80 mg capsule daily). Training groups performed an exercise protocol of HIIT training with maximum heart rate for 6 weeks (three sessions per week). Blood samples were obtained to liver enzymes measurement (ALT, AST and ALP) before and after the intervention period. Results: Performing six weeks of high intensity interval training along with taking nano-curcumin supplemen led to a significant reduction in serum level of AST and ALT compared to control group (P<0. 05). In the supplement-training group, a significant decrease was observed in serum levels of ALT and AST compared to pre-test (P<0. 05). But no statistically significant changes were observed in ALP serum level. Conclusion: It seems taking nano-curcumin supplement along with high intensity interval training have a favorable effects on improving some of the liver characteristics of overweight female students.

Background and Objective: Alteration of scapular position and motion are called scapular dyskinesis (SD), that leads to symptoms such as pain in the shoulder joint. This study was performed to determine the effect of eight weeks scapular stabilization exercises on shoulder pain of archer men with scapular dyskinesis. Methods: In this clinical trial study 30 archer men of recurve sport field with SD and shoulder pain were randomly divided into two intervention and control groups. Shoulder pain of all subjects was evaluated by using numeric pain rating scale. Then the interventional groups were received scapular stabilization exercises in three sessions per week for eight weeks. The control group performed only their normal daily exercises. At the end of the training, post-test was performed for both groups. Results: The results of the present study showed that after scapular stabilization exercises, the reduction of dominant shoulder pain both during exercise and at rest was significant in interventional group in compared to controls (P<0. 05). But in Non-dominant shoulder, there was significant effect in pain reduction only in intergroup (P<0. 05) and there was no significant effect between interventional and control groups. Conclusion: Scapular stabilization exercises can use to reduce the pain of dominant shoulder joint of archer sport men with scapular dyskinesis.

Background and Objective: Stroke and cerebral ischemia are the second leading causes of death in the world. Currently, there are limited therapeutic interventions for patients with ischemia / reperfusion. This study was performed to determine the protective effect of aerobic exercise and adenosine on changes in inflammation mediators after transient ischemia of common carotid arteries in male Wistar rats. Methods: In this experimental study, fifty male Wistar rats were randomly allocated into to 5 groups: control, cerebral ischemic control, aerobic exercise + cerebral ischemia, adenosine + cerebral ischemia and aerobic exercise + adenosine + cerebral ischemia. Ischemia was performed by blocking the common carotid artery for 45 minutes after a period of exercise and injection of adenosine. Neuronal structure was examined by Nissel tissue staining. The expression of NGF and Glutamate genes were measured in CA1 region of hippocampal tissue samples. Results: Cell death was increased in neurons in the CA1 region of the hippocampus in the ischemia / reperfusion group, While a significant reduction in cell death in the adenosine + ischemia / reperfusion and aerobic exercise + ischemia /reperfusion groups was due to adenosine administration and aerobic exercise (P<0. 05). NGF and glutamate gene expression in the adenosine + ischemia/reperfusion and adenosine + aerobic exersice + ischemia/reperfusion groups significantly increased and reduced compared to the ischemia/reperfusion control, respectively (P<0. 05). Conclusion: Co-administration of adenosine combined with aerobic exercise increase the protective effect of aerobic exercise on improving the neuronal damage after ischemic / reperfusion.

Background and Objective: Foot pronation could increase injury occurrence during running. This study was done to investigate the effect of shoes with spikes containing two different stiffness on frequency spectrum of muscles during running in patients with pronated feet. Methods: This quasi-experimental study was done on15 pronated feet runners with mean age of 27. 2±, 6. 4 years. Running was done in two conditions including double density and usual spikes Track and field shoes with between rests of 5 minutes. A wireless 8 channels electromyography system (UK) with bipolar electrodes was used to record the electrical activity of the lower limb muscles. Electrodes were located on tibialis anterior, medial gastrocnemius, vastus medialis, retus femoris, vastus lateralis, biceps femoris, semitendinosus, and gluteus medius muscles in accordance with SENIAM European protocol. Results: Frequency content of tibialis anterior and gluteus medius at loading phase were significantly greater during running with spikes double density Track and field shoes compared with usual spike shoes (P<0. 05). The frequency content of muscles did not demonstrate any significant differences during running with spikes double density Track and field shoes compared with usual spike shoes at both mid-stance and push-off phases. Conclusion: The double density spikes track and field shoes increased frequency content of tibialis anterior and gluteus medius muscles during loading phase that could be associated with shock absorption.

Background and Objective: Colorectal cancer is one of the most common cancers and considered to be leading causes of cancer death in the world. One of the problems with this type of cancer is its inability to be detected in early stage. The aim of present study was to evaluate the correlation between the serum levels of Fucosyltransferase-4 and galactin-3 in patients with early-stage of colorectal cancer. Methods: This case-control study was done on 40 patients with early stages of colorectal cancer and 40 healthy subjects. ELISA method was used to measure the serum levels of Fucosyltransferase-4 and galactin-3. To examine the correlation between the variables, correlation test and Pearson correlation coefficient index were used. Results: Fucosyltransferase-4 and galactin-3 levels were higher in patients with early-stage of colorectal cancer compared to healthy subjects. This difference was not significant. In patients with colorectal cancer, there was a significant relationship between the level of Fucosyltransferase-4 and galactin-3 (r=0. 71, P=0. 01). Conclusion: Simultaneous measurement of Fucosyltransferase-4 and galactin-3 is useful in identifying early-stage of colorectal cancer as a non-invasive laboratory method.

Background and Objective: Obesity plays an important role in the development of chronic diseases including diabetes, hyperlipidemia, and cardiovascular diseases (CVD). This study was conducted to evaluate the association of the age of onset of obesity with resting metabolic rate (RMR) in overweight and obese women during adulthood. Methods: This descriptive-analytical study was done on 295 overweight and obese women aged 18-50 years in Tehran, Iran. The anthropometric measurements of all participants were measured. Dietary intake and total daily energy intake were assessed by using a semi-quantitative food-frequency questionnaire (FFQ) which the list including 147 food items. Resting metabolic rate was measured by indirect calorimetric method. In order to measure the physical activity International Physical Activity Questionnaire (IPAQ) was used. The questionnaire includes 7 items to assess the intensity of activities by the vigorous, medium, and light for at least 10 minutes during the last week. Results: There was a significant difference between those whose age of onset of obesity was under 18 or over 18, in RMR per body weight (kg) (Beta: 0. 16, CI: 0. 11 to 0. 00, P: 0. 03). In addition, it was seen a significant inverse correlation between age of onset of obesity and body weight (Beta:-0. 11, CI:-0. 30 to 0. 00, P: 0. 005) and adipose tissue content (Beta:-0. 13, CI:-0. 23 to-0. 01, P: 0. 02). After adjustment for confounders including (age, physical activities, and energy intake), the correlations still remain significant. Conclusion: Age of onset of obesity was associated with increased weight and fat and decreased resting metabolic rate in adulthood. In fact, people with lower obesity age have higher body weight and fat and lower RMR.

Background and Objective: Psoriasis is one of the most common inflammatory skin diseases. About 37 to 50% of patients report exacerbation of symptoms following psychological stress. This study we done to determine the frequency of personality disorders in psoriatic patients in north of Iran. Methods: This descriptive-analytical study was performed on 128 psoriatic patients referred to the dermatology clinic of Sayyad Shirazi Hospital and private clinics in Gorgan, north of Iran during 2019. Firstly severity of psoriasis was determined based on the PASI score (PASI: Psoriasis Area and Severity Index). Then, personality disorders were assessed using the Millon MCMI-III multivariate questionnaire. Results: The mean age of psoriasis patients was 40. 84±, 12. 91 years and the duration of the disease was 8. 87±, y7. 62 ears. 72. 7% of patients were females. The prevalence of most personality disorders was histrionic (22. 7%), depressive (6. 3%) and obsessive-compulsive personality disorder (3. 1%), respectively. There was a significant relationship between histrionic personality disorder, which was the most common personality disorder, with disease severity, education level and type of treatment (P<0. 05). There was significant relationship between depressive personality disorder and level of education, gender, occupation and ethnicity (P<0. 05). Conclusion: The most common personality disorder in psoriatic patients was histrionic personality disorder.

Background and Objective: Vitamin D increases muscle strength through protein synthesis and myogenesis and may play an important role in anaerobic and aerobic activities. This study was done to determine the vitamin D status and its relationship with physical function indexes in young Taekwondo athletes. Methods: This descriptive-analytical study was conducted on 75 young male Taekwondo athletes, aged 18-23 years that were selected using randomized sampling method. Serum 25-hydroxyvitamin D level was measured by ELISA method. The 20-meter shuttle run, running based anaerobic sprint (RAST), vertical jump, 36-meter sprint and Illinois agility tests were used to determine aerobic and anaerobic capacities, explosive anaerobic power of the lower limbs, speed and agility, respectively. Body mass index and percent body fat was measured for each subject. Level below 20, 20-30 and more than 30 ng/ml of serum 25-hydroxyvitamin D were considered as vitamin D deficiency, insufficiency and normal status, respectively. Results: The results showed that 48% (36 athletes) and 42. 66% (32 athletes) of taekwondo athletes had deficient and insufficiency levels of vitamin D, respectively. Also, a significant correlation was detected between serum 25hydroxyvitamin D concentration and aerobic power (r=0. 897), anaerobic power (r=0. 901), vertical jump performance (r=0. 855), fatigue index (r=-0. 838), agility (r=-0. 634) and 36 meters sprint (r=-0. 793) times (P<0. 05). However, this association was significant in athletes with lower than normal levels of vitamin D (P<0. 05), no association was found in subjects with normal vitamin D levels. Conclusion: Vitamin D of 90. 66% of young taekwondo practitioners was lower than normal level. Increasing in vitamin D level can improve the physical performance of young athletes with vitamin D deficiency or insufficiency status.

Background and Objective: Overexposure to electromagnetic waves produces by computer cause health disorders by users. This study was performed to determine the employer's exposure risk to electromagnetic fields from monitors of computers in north of Iran Methods: This descriptive-analytical study was performed on 100 of computers using by 100 employee users (69 males and 31 femals) with the mean age of 40. 83±, 7. 37 in Gomishan county, Golestan province in north of Iran during 2018. The intensity of the magnetic and electric field caused by computers was measured at 30, 50 and 60 cm intervals and in four directions from the front, back, right and left side of the monitor using SVENSK standard method. The intensity of fields was measured by TM-190 instrument. Data were compared with OEL (Occupational Exposure Limit), MPRII and TCO (The Swedish Confederation of Professional Employees). The NIOSH (National Institute for Occupational Safety and Health) standard questionnaire was used to assess the side effects of working with computers. The health problems in employee users were recorded. Results: The mean±, SD of the intensity of the electrical waves was 103. 63±, 33. 62 v/m that was less than the standard values. The mean±, SD of the intensity of the magnetic waves was 0. 1±, 0. 09 mA/m that was higher than the TCO, MPRII standard values and less than OEL. The maximum magnetic-field invasion from the standard range with an average of 157. 04 mA/m is on the front of the monitors, at a distance of 30 cm and the lowest of them with a mean of 19. 2 mA/m for the off-mode computer and at a distance of 60 cm from the mantle. There was a significant difference between the time of working with computer in the day with burning eye, headache and eye fatigue. There were no significant difference of clinical symptoms in men and women and fatigue syndrome. Conclusion: The electrical waves of monitor of computers were lower than standard limit in all studied conditions, but the magnetic waves were much higher than standard limit.

Background and Objective: Streptomyces are gram-positive and aerobic bacterial strains that are isolated from different sources. Streptomyces have the ability to produce secondary metabolites and biologically active substances and are therefore very important in the field of biocontrol. Urate oxidase is a microbial enzyme product that can be extracted from a variety of sources, including streptomycin. In the present study, cloning of the urate oxidase gene isolated from seawater streptomycosis was performed in Escherichia coli Origami bacteria. Methods: In this descriptive study, a total of 60 water and sediment samples were collected from different depths of the Caspian Sea coast in Mazandaran province, Iran. The Geram, staining methyl red, VP, citrate, starch hydrolysis, casein hydrolysis, nitrate reduction, oxidase and catalase tests were performed to identify and isolate Streptomyces. The urate oxidase gene was cloned using the T-A cloning method using the PTG-19 vector inside the host of Escherichia coli Origami. The expression of cloned genes in recombinant colonies was investigated by Real-Time PCR. The phylogenetic tree was drawn using clustalX and Mega5 software. Results: Screening of marine water samples identified 12 isolated streptomyces, all of which had the urate oxidase gene. The expression of urate oxidase gene in Escherichia coli Origami was confirmed by Real-Time PCR. The results of phylogenetic studies identified some close relatives of Streptomyces as candidates for subsequent studies. Conclusion: Streptococcus bacteria can be considered as a rich source of secondary metabolites with many applications and can be used as a native to produce the enzyme urate oxidase. By using different cloning hosts and examining optimal production conditions, this strain can be a candidate for future studies to develop antimicrobial drugs and compounds.

Background and Objective: One of the most important attempts in crisis is the nutrition management of affected people during and following the disaster. In March 2019, floods occurred in towns and villages on the outskirts of the Gorganrood River in Golestan province, northern Iran. This study conducted to explain the challenges of nutrition management in the flood crisis of Golestan province. Methods: In this qualitative study, 31 people affected by floods, urban and provincial managers and experts involved in crisis management were selected by purposive sampling method. Data were collected using an interview guide and semistructured in-depth interviews. Data were recorded and transcribed and analyzed using the content analysis method and Atlas. ti 8 software. Results: The managerial challenges included planning, organization, coordination, control, and evaluation. The executive challenges contained food preparation, food distribution, and monitoring. The other challenges included political, economic, cultural, and ecological challenges. Conclusion: Most of the respondents emphasized the irregularity and confusion in nutrition management during the flood and considered it as a result of managerial challenges, executive challenges, political, economic, cultural and ecological challenges.

Lycanthropy is a delusive belief that the affected person or others transform into a wolf or other animals. Lycanthropy has been known for over 2000 years. This paper introduces a 51-year-old married woman who has had symptoms of depressive disorder for the past four years, following forced marriage and has recently been diagnosed with lycanthropic syndrome. The patient was diagnosed with depression along with lycanthropy symptoms (psychotic depression) and was treated with antipsychotics, antidepressants, and individual psychotherapy. Over a 16-weeks follow-up, her lycanthropy was reduced and symptoms of depression improved relatively.