The problem of two-phase MHD boundary layer flow, heat and mass transfer over a stretching sheet with fluid-particle suspension and thermal radiation has been studied. The e ect of mass transfer in dusty uid over a stretching sheet is considered for the first time. The governing equations are reduced to a set of non-linear ordinary differential equations under suitable similarity transformations. The transformed equations are then solved numerically. The influence of various physical parameters such as magnetic parameter, fluid-particle interaction parameters, Prandtl number, Eckert number and thermal radiation parameter on velocity, temperature and concentration of both fluid and particle phase is analyzed. The numerical results of the present investigation were compared with previously published results and found to be an excellent agreement. It is found that, the momentum, thermal and solute boundary layer thickness of both fluid and dust phase are reduced for higher values of mass concentration of suspended dust particles.