Introduction & Objective: Spinal epidural abscess (SEA) is an infective and devastating disease of spinal canal that needs the prompt clinical diagnosis and treatment. Delay in appropriate intervention will result to irreversible nervous complications. In this article with introduction of two patients, we try to choose an optimal approach with minimal manipulation and least destruction to prevent the instability and to achieve best results. Two cases will be introduced. The first one is a 17-year-old girl with progressive quadriparesis and diagnosis of extensive epidural abscess from cervical to lumbar region and the second case, who was a 38-year-old man with abscess from thoracic to lumbar region. Two cases were operated with minimal manipulation and prevented of postoperative instability, was prevented. Inspite of rapid progression and irreversible complication of SEA, good result and prevention of complication and instability can be obtained with choice of restrict surgical procedure and minimal invasion.