In this study, the results of a direct numerical simulation of turbulent drag reduction ina channel flow by hydrophobic coating at a nominal shear Reynolds number of Re t=180 are reported. Slip condition is imposed on the lower wall whereas the upper wallhas no-slip condition. For this purpose, the use is made of a numerical simulation of three-dimensional, time-dependent Navier-Stokes equations for the incompressibleflow of a Newtonian fluid. Finally, statistical quantities of turbulent flow (specificallythe mean velocity profile, the root-mean-square of velocity fluctuations in differentdirections and the Reynolds shear stress are shown and discussed. The results confirmthat by increasing the amount of slip on the lower wall, the bulk velocity passingthrough the channel increases. Also, the variation of root-mean-square of velocityfluctuations shows a similar behavior in the vicinity of the upper wall. But, theirgeneral trend is different in the proximity of the lower wall. Moreover, a change in theshape of the Reynolds shear stress profile from a minimum close to the lower walltowards a maximum close to the upper wall is observed.