Ovarian tumors are one of the most common neoplastic diseases in women. p53 is a nuclear phosphoprotein, and its mutant form has an oncogenic role in many human cancers. In this study, p53 expression in benign, borderline and malignant ovarian tumors is assessed, and then its relationship with tumor histology, clinical factors and the stage of disease is evaluated. 50 cases of ovarian epithelial tumors including 24 malignant, 6 borderline, and 20 benign tumors, were collected. The expression of p53 was studied immunohistochemically using paraffin embedded ovarian epithelial neoplastic tissue. The correlation between p53 expressions in ovarian epithelial tumors and clinicopathologic variables were analyzed. None of the benign tumors were positive for p53, but 66% of the malignant tumors and 16.6% of borderline tumors were positive. There was no significant association between p53 protein expression and histopathologic type of malignant tumors (P=0.85), stage of disease (P=0.3) and the age of patients (P=0.39). P53 can be detected in malignant ovarian epithelial tumors. There was no significant relationship between p53 expression and clinical or histopathologic variables. According to the results of the study, other expanded studies about p53 role in prognostic, and therapeutic approaches, are recommended.