N, N' -Dibromo- N, N' -1, 2-ethanediyl bis (p-toluene sulfonamide) [BNBTS] as a reusable catalyst promoted one-pot synthesis of benzo [c] acridines in good to high yields under three-component reaction from anilines, aldehydes and cyclic 1, 3-dicarbonyl compounds under solvent-free conditions.

The ongoing endeavor to synthesize new antibacterial compounds is essential in overcoming bacterial resistance, as this poses a serious threat to the survival of the human race. This research work aimed to synthesize new amide derivatives of fused imidazole and acridines due to their high potential and remarkable biological history. To accomplish this objective, various derivatives of 3H-imidazo[4,5-a] acridines were prepared and then transformed into new amide derivatives under acidic conditions. The novel compounds were characterized based on spectral analysis, including FT-IR, 1H NMR, and 13C NMR spectra, along with additional analytical data. Antibacterial testing was conducted on the compounds, assessing their activity against a variety of bacterial strains, encompassing both gram-negative and gram-positive species. Minimum Inhibitory Concentration (MIC) values were recorded. The findings of the antimicrobial screening tests demonstrated that the compounds exhibit a high level of efficacy against both bacterial strains. Their Minimum Inhibitory Concentration (MIC) values are similar to well-known antibacterial agents such as Ciprofloxacin. Additionally, the compounds exhibited cytostatic properties in the higher micromolar range. By utilizing the molecular docking method, the binding sites of compounds with the dihydrofolate reductase enzyme were determined.

This study assesses the corrosion inhibition effectiveness of Acridine and its derivatives Acridine -ACD, Acridine-2-Carboxylic Acid-ACA, Acridine-2-Carbaldehyde-A2C, and 2-Ethyl –Acridine -2EA on Al (110) surfaces using quantum chemical analysis. Computational chemistry techniques were employed to calculate the binding energies of these inhibitors, which were found to be -39.918 kcal/mol for ACD, -53.042 kcal/mol for ACA, -47.001 kcal/mol for A2C, and -46.319 kcal/mol for 2EA. Besides binding energies, various Fukui functions and energy parameters were analysed, including EHOMO (The Highest Occupied Molecular Orbital Energy), ELUMO (The Lowest Unoccupied Molecular Orbital Energy), ΔE (Energy Gap), ΔNAl (Charge Transfer to the Aluminum Surface), ω (Stability Index), and ΔE_b-d (Binding Energy Difference). Among the tested inhibitors, ACA demonstrated the highest binding energy across all parameters, indicating the strongest interaction with the aluminum surface. The Fukui function study revealed that atoms C1, C13, N6, and N7 exhibited higher Fukui values for both Fukui (+) and Fukui (-), suggesting these atoms play a crucial role in the interaction with the aluminum surface. ACA's optimal electronic and binding properties enable it to form a robust protective layer on Al (110), significantly enhancing corrosion resistance. In conclusion, ACA emerged as the most effective corrosion inhibitor among the Acridine derivatives studied, providing superior protection for Al (110) surfaces.