Background: Eagle-BARRETT syndrome is a rare congenital anomaly of uncertain etiology almost exclusive to males. It is characterized by the triad of absent or incomplete abdominal musculature, undescended testes, and urinary tract abnormalities. A male newborn with above characteristics triad hospitalized in our NICU. Diagnosis of Eagle – BARRETT Syndrome has been made. He was second child of none-relative parents. Abdominal examination revealed huge distension with thin and wrinkled skin protruding most prominently in the right side with visible bowel loops. Both kidneys were palpable. He had bilateral cryptorchidism. Lower limbs examination showed clubfoot abnormality of right foot. Cardiac examination showed a small ASD. Ultrasound imaging showed moderate bilateral hydronephrosis with bladder trabeculation with gross dilatation pelvicalyceal system of left kidney and distended bowel loops.

Background: Because of confusion to gastric cancers arising at the gastro-esophageal junction, true esophageal adenocarcinoma was thought to be unusual. Esophageal adenocarcinoma (EAC) is becoming more common worldwide with increasing incidences. Material and Methods: Overexpression of decoy receptor (DcR) 3 protein, - a recently discovered member of the tumor necrosis factor receptor super-family, was examined in 60 esophagogastrectomy specimens containing areas of BARRETT esophagus (n = 27), low-grade dysplasia (n = 40), high-grade dysplasia or carcinoma in situ (n = 33), and esophageal adenocarcinoma (EAC; n = 42) with immunohistochemical analysis. All cases were retrieved from the pathology files of Damanhour national medical institute hospital. Results: The results of this study revealed more overexpression of DcR3 in high-grade dysplasia or carcinoma in situ and EAC than in benign esophageal mucosa (both P < 0.0001), BARRETT esophagus (both P < 0.001), and low-grade dysplasia (P < 0.01 and P = 0.033, respectively) significantly. Low-grade dysplasia also showed significant overexpression of DcR3 compared with benign esophagus (P < 0.05) but not with BARRETT esophagus (P > 0.05). DcR3 overexpression seems negatively correlated with the grade of EAC. Conclusion: Results of this study suggest that overexpression of DcR3 protein might be an aid in the diagnosis of high-grade dysplasia or carcinoma in situ and EAC and also might serve as a potential therapeutic target.

Background: Helicobacter pylori is an important pathogen in the upper digestive tract. It is of great significance to properly understand the risk factors for the transformation of BARRETT esophagus into esophageal carcinoma. However, the relationship between H. pylori and gastroesophageal reflux disease (GERD) and BARRETT esophagus remains controversial, and the correlation with immune function has been rarely reported. Objectives: This study investigated the effect of H. pylori infection on BARRETT esophagus and its correlation with immune function. Methods: We recruited 40 patients with BARRETT esophagus (BARRETT esophagus group) and 40 patients with GERD (GERD group). In addition, 40 healthy controls were selected for the control group. Esophageal function and its correlation with immune function were measured in each group. Results: The positivity rate of H. pylori (P< 0. 05)andsphincter pressure were lower in both BARRETT esophagusandGERDgroups than in the control group, while the levels of PGI, PGII, PGI/II, and G-17 were higher (P < 0. 05). The levels of CD3+, CD4+, and CD4+/CD8+ were lower in the BARRETT esophagus group than in the GERD group, but they were negatively correlated (P < 0. 05) with H. pylori infection. The level of CD8+ was higher in the BARRETT esophagus group, and it was positively correlated (P < 0. 05) with H. pylori infection. Conclusions: Helicobacter pylori infection may protect against BARRETT esophagus by reducing gastric acid secretion and increasing lower esophageal sphincter pressure. Besides, it has a certain correlation with immune function.

Aim: Identification of crucial genes and possible biomarkers which are involved in BARRETT’ s esophagus (BE) disease was aim of this study. Background: BE is diagnosed by endoscopy and biopsy and is characterized by esophageal columnar metaplastic epithelium. BE can convert into dysplasia that finally results cancer condition. Methods: Gene expression profiles of BE and normal gastric cardia which are characterized by GSE34619 and GPL6244 platform (1) were retrieved from gene expression omnibus (GEO). The significant differentially expressed genes (DEGs) were analyzed via protein-protein interaction network (PPI) analysis. The nodes of network were enriched via gene ontology (GO) to find biological terms. Action map of network elements was provided. Results: Among 250 top DEGs, 100 ones were included in PPI network and KIT, CFTR, IMPDH2, MYB, FLT1, ATP4A, and CPS1 were recognized as prominent genes related to BE. Seven amino acids including arginine, alanine, aspartate, glutamate, valine, leucine and isoleucine which are related to BE were highlighted. Conclusion: In conclusion five central DEGs; KIT, CFTR, IMPDH2, MYB, and FLT1 were proposed as possible biomarkers for BE. However, validation and more experimental information is require to finalize the findings.