ASSESSMENT OF USE OF DCR 3 IN DIAGNOSIS OF DYSPLASTIC LESIONS AND ADENOCARCINOMA OF THE ESOPHAGUS

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SHALABY A.M.R.; AL REFAEY H.K.

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Journal: DARU Journal of Pharmaceutical Sciences Year:2007 | Volume:15 | Issue:4 Page(s): 188-192

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Information Journal Paper

Title

ASSESSMENT OF USE OF DCR 3 IN DIAGNOSIS OF DYSPLASTIC LESIONS AND ADENOCARCINOMA OF THE ESOPHAGUS

Author(s)

SHALABY A.M.R. | AL REFAEY H.K. | Issue Writer Certificate

Keywords

ESOPHAGEAL ADENOCARCINOMA

BARRETT ESOPHAGUS

Abstract

Background: Because of confusion to gastric cancers arising at the gastro-esophageal junction, true ESOPHAGEAL ADENOCARCINOMA was thought to be unusual. ESOPHAGEAL ADENOCARCINOMA (EAC) is becoming more common worldwide with increasing incidences. Material and Methods: Overexpression of decoy receptor (DcR) 3 protein, - a recently discovered member of the tumor necrosis factor receptor super-family, was examined in 60 esophagogastrectomy specimens containing areas of BARRETT ESOPHAGUS (n = 27), low-grade dysplasia (n = 40), high-grade dysplasia or carcinoma in situ (n = 33), and ESOPHAGEAL ADENOCARCINOMA (EAC; n = 42) with immunohistochemical analysis. All cases were retrieved from the pathology files of Damanhour national medical institute hospital. Results: The results of this study revealed more overexpression of DcR3 in high-grade dysplasia or carcinoma in situ and EAC than in benign esophageal mucosa (both P < 0.0001), BARRETT ESOPHAGUS (both P < 0.001), and low-grade dysplasia (P < 0.01 and P = 0.033, respectively) significantly. Low-grade dysplasia also showed significant overexpression of DcR3 compared with benign esophagus (P < 0.05) but not with BARRETT ESOPHAGUS (P > 0.05). DcR3 overexpression seems negatively correlated with the grade of EAC. Conclusion: Results of this study suggest that overexpression of DcR3 protein might be an aid in the diagnosis of high-grade dysplasia or carcinoma in situ and EAC and also might serve as a potential therapeutic target.

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APA: Copy

SHALABY, A.M.R., & AL REFAEY, H.K.. (2007). ASSESSMENT OF USE OF DCR 3 IN DIAGNOSIS OF DYSPLASTIC LESIONS AND ADENOCARCINOMA OF THE ESOPHAGUS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 15(4), 188-192. SID. https://sid.ir/paper/275425/en

Vancouver: Copy

SHALABY A.M.R., AL REFAEY H.K.. ASSESSMENT OF USE OF DCR 3 IN DIAGNOSIS OF DYSPLASTIC LESIONS AND ADENOCARCINOMA OF THE ESOPHAGUS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2007;15(4):188-192. Available from: https://sid.ir/paper/275425/en

IEEE: Copy

A.M.R. SHALABY, and H.K. AL REFAEY, “ASSESSMENT OF USE OF DCR 3 IN DIAGNOSIS OF DYSPLASTIC LESIONS AND ADENOCARCINOMA OF THE ESOPHAGUS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 15, no. 4, pp. 188–192, 2007, [Online]. Available: https://sid.ir/paper/275425/en

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