Objective: This study analyzes the effects of lifestyle, nutrition, and diets on the status and risks of apparent (symptomatic)COVID-19 infection in Iranian families. Materials and Methods: A relatively extensive questionnairesurvey was conducted on more than 20, 000 Iranian families(residing in more than 1000 different urban and rural areas in theIslamic Republic of Iran) to collect the big data of COVID-19 and develop a lifestyle dataset. The collected big data included therecords of lifestyle effects (e. g. nutrition, water consumptionresources, physical exercise, smoking, age, gender, health and disease factors, etc. ) on the status of COVID-19 infection infamilies (i. e. residents of homes). Therefore, an online selfreported questionnaire was used in this retrospective observationalstudy to analyze the effects of lifestyle factors on the COVID-19risks. The data collection process spanned from May 10, 2020 toMarch 19, 2021 by selecting 132 samples from more than 40different social network communities. Results: The research results revealed that food and water sources, which contain some natural hypomethylating agents, mitigated the risks of apparent (symptomatic) COVID-19 infection. Furthermore, the computations on billions of permutations ofnutrition conditions and dietary regime items, based on the data collected from people’, s diets and infection status, showed thatthere were many dietary conditions alleviating the risks ofapparent (symptomatic) COVID-19 infection by 90%. However, some other diets tripled the infection risk. Conclusion: Some natural hypomethylating agents in food, water, and environmental resources are against the spread and risks ofCOVID-19.