Introduction: A bioresonance-based complementary treatment for corneal ulcers is described to determine whether an electromagnetic fi eld can improve intractable corneal ulcers. Case Presentation: The patient was a 65-year-old man who was suff ered from corneal ulcer. The wound was burned fi ve times with laser surgery; however, there was no signifi cant improvement in the patient’ s condition. He had been treated for a year with electromagnetic frequency complements. Conclusions: Since bioresonance therapy can heal the corneal ulcer in this patient, we advised patients to perform this treatment.

Introduction: Phantom limb pain (PLP) is a sensation caused by missing an organ in the body, which can be due to amputation. The prevalence of PLP due to amputation is about 82% for upper limbs and 54% for lower limbs. Case Presentation: This research describes the case of a 71-year-old female patient who developed PLP after having three middle fi ngers on her left hand amputated due to dipping in a meat grinder. She underwent bioresonance therapy for PLP treatment for 19 months and achieved positive results. Conclusions: Regarding the role of PLP in the patients undergoing amputation, bioresonance therapy might be benefi cial in managing this condition.

Introduction: Every year, more than 64 million people suffer from traumatic brain injury that can cause psychological disorders. Case Presentation: The patient is a 21-year-old man with behavioral and emotional changes since 5 years ago after multiple traumas. He was referred to the Bioresonance Center and treated with electromagnetic complements for 6 months. After using the complement, speech comprehension and aggressive behaviors improved.

Background: The side effects of therapies such as chemotherapy (CT), radiotherapy (RT) and surgery in cancer patients are very high. For this reason, even when recovery is achieved in cancer, life is often shortened due to the side effects of treatments. Bioresonance treatment (BRT) on cancer is intended to reduce cancer-related complaints such as pain, nausea and weakness or treatment side effects. Materials and Methods: In this study, BRT effects have been evaluated according to the performance status, symptomatic recovery after the therapy in cancer patients treated with the BICOM BRT with or without RT or CT. We used to Ai programs, harmonious inverted and disharmonious inverted (Hi-Di) programs for the treatment of, pain, nosea, dispnea etc. complaints with using local electrods of BICOM machine. Results: A statistically significant difference was found between the treatment response averages of BRT application groups according to ECOG performance (Eastern Cooperative Oncology Group performance) scale. It is understood that the BRT treatment response was obtained later sessions of the group wich have better scoring (p = 0. 005). Conclusion: The treatment response of with worse ECOG performance scoring of patients was better in early sessions than late sessions of BRT. Whereas the response time was shorter than the late responding patients. BRT method decreased to side effets of conventional cancer therapies also increased to the quality of life and palliation of patients.

Introduction: Cutaneous leishmaniasis (CL) is one of the infectious diseases and health problems in tropical regions. Glucantime is commonly used to treat CL and it, not only has some side effects but also observation shows the drug resistance of some of the various Leishmania species. Therefore, the aim of this study was to investigate the effect of silver nanoparticles (AgNPs) and bioresonance waves on Leishmania, in vitro. Materials and Methods: In the present experimental study, Leishmania major promastigotes were cultured in RPMI-1640 supplemented with 10% FBS and 1% penicillin and streptomycin at 23° C. After 6 days, the parasites achieved stationary phases of promastigotes, Then the effects of different concentrations of AgNPs (1, 3, 5, 10 and 25 μ g/mL) and different radiation times of bioresonance wave (5 and 20 minutes) were investigated. Herein, the effects of various treatment on parasites proliferation were evaluated with live promastigotes counting after 24, 48 and 72 hours treatment. Results: The parasite count showed that the various concentrations of AgNPs, radiation of bioresonance wave and combination significantly decreased the numbers of live promastigotes over time compared with the control group after 72 hours. The highest antileishmanial activity was seen for AgNPs at concentration of 1 μ g/mL when combined with 20 minutes radiation of bioresonance wave (proliferation inhibition: 79. 92%) Conclusions: Based on our result, AgNPs and bioresonance waves are potent antileishmanial agents. The authors declare that the more studies should be done.

Feline infectious peritonitis (FIP) continues to be one of the most researched infectious diseases of cats. The diagnosis of FIP is challenging, and diverse techniques have been developed for its accurate diagnosis. However, they have some limitations. The present study was conducted to investigate the efficacy of specific modulation frequency (SMF), compared to other routine diagnostic methods for detecting feline coronavirus. Blood samples were collected from 30 diseased cats suspected of having FIP based on clinical signs. Electrophoresis, polymerase chain reaction (PCR), and SMF tests were performed for each sample. The sensitivity and specificity of each test, as well as the agreement between the tests and the gold standard (the combination of PCR, electrophoresis, and bioresonance results), were calculated using the Kappa coefficient method. The sensitivity and specificity of electrophoresis, PCR, and SMF for the diagnosis of FIP were 70.6%, 70.6%, 100%, and 100%, 72.7%, 81.8%, respectively. According to the findings of the present study, SMF is effective and safe in FIP diagnosis, which is a challenge in veterinary medicine diagnosis.

Dear Editor-in-chief: Due to the side effects of drugs and resistance to the used chemicals in the treatment of tropical diseases such as malaria, leishmaniosis, trypanosomiasis and Schistosomiasis, which millions of people around the world are infected, nowadays nanomedicine usage with the production of nanofibers and nanoparticles (nanopowders, nanocrystal or nanocluster). The particles with a diameter of less than 100 nanometers is considered as a special treatment in parasitic diseases 1, 2. Due to the intracellular nature of some parasites, their treatment is a major challenge for researchers to develop new drugs. Findings show that Chitosan nanoparticles and metals such as silver, gold, and metal oxides have a lethal or inhibitory effect on various parasites, including giardiasis, leishmaniosis, malaria, or toxoplasma and insect larvae 1. The effects of drug release from chitosan nanofibers have also been performed in various external and internal evaluations on lesions caused by Leishmania major and the therapeutic effect of gold and silver nanoparticles on malaria and their concomitant use with bioresonance waves on leishmaniasis 2, 4. The main purpose of using nanoparticles is to use it as a drug delivery system and to release the drug agent in order to affect the specific site. Recently, the use of particle systems such as nanomedicine as a physical tool to improve the pharmacokinetic properties of various types of drug molecules in vivo is being developed 1, 4. The endocytic pathway transfers nanoparticles to the site of pathogens. The breakdown of these substances by lysosomal enzymes releases drugs into the phagocytic or lysosomal vesicle, or this process is released into the cytoplasm by a diffusion phenomenon. Specific transmission depends on the physical and chemical nature of the molecules 1. In recent years, the use of nanoparticles for the treatment of parasitic diseases has considered, although limited research has conducted in this regard (Table 1). Finally, it can be concluded that according to recent findings on the inhibitory and long-term effects of nanofibers and nanoparticles on different parasites with less side effects than conventional drugs, more effective and less side effects drugs can be developed. Useful vaccines have also been developed to control parasitic diseases.