Bleomycin is a widely used antineoplastic drug which produces dose and time-dependent interstitial pulmonary fibrosis in human and animals. The mechanism of Bleomycin-induced lung injury is not well understood. However, current studies have shown that Bleomycin can generate free oxygen radicals such as super -oxide and hydroxyl radical. In this study the antioxidant effect of vitamin C in biological system and its effect on Bleomycin-induced lung fibrosis in rat have been investigated. In this study rats were divided into four groups: Control, Bleomycin and Saline, Bleomycin and vitamin C and saline and vitamin C. The degree of tissue injury in the Bleomycin and vitamin C group was significantly lower than Bleomycin and saline group. Results of this study suggest that vitamin C may reduce the fibrosis formation effect of belomycin in lung tissue.      

In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of Bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final sample was injected into fibro sarcoma-bearing mice via their tail vein. Satisfactory preliminary SPECT images were acquired between 2-4 hours post-injection showing suitable accumulation in fibro sarcoma tumors

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