PREPARATION OF [111IN]-BLEOMYCIN RADIOPHARMACEUTICAL

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JALILIAN A.R.; MIRZAII M.; KARIMIAN A.R.; MOAFIAN J.; ASLANI G.; MORADKHANI S.; KAMALI DEHGHAN M.; DANESHVARI S.; TABEEI F.; RAEIS ALI GH.R.

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Journal: IRANIAN JOURNAL OF NUCLEAR MEDICINE Year:2005 | Volume:- | Issue:23 Page(s): 19-27

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Title

PREPARATION OF [111IN]-BLEOMYCIN RADIOPHARMACEUTICAL

Author(s)

Keywords

RADIOPHARMACEUTICAL

IN-111

BLEOMYCIN

FIBROSARCOMA

Abstract

In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of BLEOMYCIN to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the RADIOPHARMACEUTICAL can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final sample was injected into fibro sarcoma-bearing mice via their tail vein. Satisfactory preliminary SPECT images were acquired between 2-4 hours post-injection showing suitable accumulation in fibro sarcoma tumors

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APA: Copy

JALILIAN, A.R., MIRZAII, M., KARIMIAN, A.R., MOAFIAN, J., ASLANI, G., MORADKHANI, S., KAMALI DEHGHAN, M., DANESHVARI, S., TABEEI, F., & RAEIS ALI, GH.R.. (2005). PREPARATION OF [111IN]-BLEOMYCIN RADIOPHARMACEUTICAL. IRANIAN JOURNAL OF NUCLEAR MEDICINE, -(23), 19-27. SID. https://sid.ir/paper/528194/en

Vancouver: Copy

JALILIAN A.R., MIRZAII M., KARIMIAN A.R., MOAFIAN J., ASLANI G., MORADKHANI S., KAMALI DEHGHAN M., DANESHVARI S., TABEEI F., RAEIS ALI GH.R.. PREPARATION OF [111IN]-BLEOMYCIN RADIOPHARMACEUTICAL. IRANIAN JOURNAL OF NUCLEAR MEDICINE[Internet]. 2005;-(23):19-27. Available from: https://sid.ir/paper/528194/en

IEEE: Copy

A.R. JALILIAN, M. MIRZAII, A.R. KARIMIAN, J. MOAFIAN, G. ASLANI, S. MORADKHANI, M. KAMALI DEHGHAN, S. DANESHVARI, F. TABEEI, and GH.R. RAEIS ALI, “PREPARATION OF [111IN]-BLEOMYCIN RADIOPHARMACEUTICAL,” IRANIAN JOURNAL OF NUCLEAR MEDICINE, vol. -, no. 23, pp. 19–27, 2005, [Online]. Available: https://sid.ir/paper/528194/en

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