SELECUS THAT AFTER ALEXANDER TOOK POWER IN IRAN, FOUNDED THE CITY OF SELEUCIA IN ABOUT 307 BC. AGAINST BABYLON, ON THE WESTERN SIDE OF THE TIGRIS RIVER, WHERE THE CITY OPIS WAS LOCATED. AND SELEUCIA WAS THE CAPITAL OF SELEUCID ON THEIR WESTERN TERRITORY. BECAUSE OF SPECIFIC GEOGRAPHIC LOCATION FOR PLACEMENT OF SELEUCIA IN MESOPOTAMIA ALONG THE TIGRIS, THE MAIN ROAD CROSSES THAT CONNECTS THE CENTRAL ASIA AND IRAN TO MEDITERRANEAN COAST AND MINOR ASIA, GREEK AND NON- GREEK RESIDENTS WHO HAVE SKILLS AND ADMINISTRATIVE ABILITIES AND ARTISTIC AND COMMERCIAL, AND ALSO MINT AND WORKSHOP PRODUCTION AND LAND THE SURROUNDING FERTILE AGRICULTURAL LED ECONOMIC PROSPERITY OF THE CITY SINCE IT WAS FOUNDED TO DECLINE. SELEUCIA WAS AN INDEPENDENT CITY AND THE CITY COUNCIL DECIDED. SELEUCA AS THE CAPITAL OF THE SELEUCID HAS BEEN AN IMPORTANT AFFECT ON THE POLITICAL, CULTURAL AND ECONOMIC EVOLUTION ON THE SELEUCID PERIOD AND AFTER IT. THIS PAPER ATTEMPTS TO REVIEW ON HISTORICAL AND ARCHEOLOGICAL DOCUMENTATION STATUS IMPORTANT POSITION OF THE THIS CITY OF THE SELEUCID AND PARTHIAN PERIODS FROM Foundation TO DECLINE.