ObjectiveWe aimed to determine the relationship between serum GLUTATHIONEPEROXIDASE and febrile seizure.Materials & MethodsIn this case-control study, 43 children with simple febrile seizure (case group)were compared with 43 febrile children without seizure (control group) in termsof serum GLUTATHIONE PEROXIDASE level, measured by ELISA method. This studywas conducted in Qazvin Children Hospital, Qazvin University of MedicalSciences in Qazvin, Iran in 2012-2013. The results were analyzed and comparedin two groups.ResultsFrom 43 children 24 (53%) were male and 19 (47%) were female in childrenwith simple febrile seizure, and 26 (60%) were male and 17 (40%) were femalein febrile children without seizure (control group) (P=0.827). Serum GLUTATHIONEPEROXIDASE level was 166 U/ml (SD=107) in the case group and 141 U/ml(SD=90.5) in the control group of no significant difference.ConclusionThere was no significant relationship between serum GLUTATHIONE PEROXIDASE andsimple febrile seizure. Thus, it seems that GLUTATHIONE PEROXIDASE, an essentialcomponent of antioxidant system, does not play any role in the pathogenesis ofsimple febrile seizure.

Introduction: Important genes that may be expressed in women candidates for mastectomy due to breast cancer are important. The expression of these genes in these women can play an important role in the treatment of these patients. The aim of this study was to investigate the expression level of GLUTATHIONE PEROXIDASE and GLUTATHIONE reductase genes in mastectomies women. Procedure: After cell culture, the cell suspension was planted in 96-well microplates and treated for 24 hours in a CO2 incubator at 37 °C. To synthesize cDNA, extracted RNA molecules were used with the help of Fermentaz Revert Aid TM kit, produced in the United States. Results: The concentration of 500 micrograms of nanoparticles caused the death of more than 60% of MCF 7 cells (P< 0.001) while there was no significant difference in all concentrations of nanoparticles on the normal HEK293 cell line. Conclusion: The anti-tumor effects of zinc oxide nanoparticles were shown in increasing the expression of GLUTATHIONE PEROXIDASE and GLUTATHIONE reductase genes in MCF-7 breast cancer cell line of mastectomy candidates.

Introduction: The role of oxidative stress in pathogenesis and autoimmune diseases is well known. According to the function of the enzyme GLUTATHIONE PEROXIDASE via its antioxidant role in the body, the aim of this study was to investigate the level of salivary GLUTATHIONE PEROXIDASE in patients with Hashimoto's thyroiditis compared to a control group. Materials & Methods: In this case-control study, 30 patients with Hashimoto's thyroiditis and 30 healthy subjects were studied as a control group. The two studied groups were the same in terms of age and gender. Five ml of total unstimulated saliva of the subjects was collected under resting conditions in a quiet room between 10 a.m. and 12 noon (spitting method). The amount of GLUTATHIONE PEROXIDASE in the saliva samples of these subjects was measured using the ELISA method. The results were analyzed using Mann-Whitney and chi-square statistical tests at a significance level of 0.05. Results: The results showed that the mean age of the participants was 36.96±8.85 years. Totally, 71.7% of the participants were women with a mean age of 37.74±8.29 years and 28.3% were men with a mean age of 35±9.24 years. The level of salivary GLUTATHIONE PEROXIDASE was significantly lower in patients with Hashimoto's thyroiditis (13.26±13.55) than in the control group (24.95±18.06, P<0.002). Conclusion: The level of salivary GLUTATHIONE PEROXIDASE in patients with Hashimoto's thyroiditis was significantly reduced than normal. Foods rich in antioxidants, especially GLUTATHIONE, are recommended. Keywords: Saliva, GLUTATHIONE PEROXIDASE, Hashimoto Disease, Thyroid