Background: With advent of modern chemotherapy regimens acute lymphocytic leukemia (ALL) has gained a much better prognosis in adults. Hyper-CVAD is an effective regimen with over a decade of experience but studies on outcomes in different populations are scarce.Methods: All adult ALL patients who were admitted for the first time to the Hematology and Oncology ward of Imam Khomeini Hospital, between October 2007 and February 2009 were recruited. The patients underwent hyper-CVAD regimen and short-term outcomes were measured.Results: Thirteen male and ten female patients with a median age of 27 y were recruited. Flocytometry showed 14 (61%) pre-B, 3 (13%)T, 5 (22) B and 1 (4%) unknown of subtypes of lymphocytic leukemia. Cytogenetic abnormalities were identified in 4 patients which were t (9;22), Klinefelter 47 (xxy)+trisomy 5, hyperdiploidy and tetraploidy. In response to our induction 18 (78%) went into complete remission (CR) and 3 patients (13%) became refractory. We also had 2 (9%) mortality of induction phase. Fever and neutropenia as our complications were seen in 12 (52.2%) patients. 9 (39.1%) patients was our mortality rate (2 during induction, 2 in consolidation, 4 after relapse with salvage and 1 with salvage being refractory).Discussion: Short-Term outcome of hyper-CVAD regimen shows a poorer prognosis compared with other reported data probably attributed to a different genetic background and clinical settings which warrants further long-time investigations in our population.