Inflammatory endobronchial POLYP is a rare disease mostly encountered in asthmatic patients. Chronic airway and foreign material irritation or thermal injury may result in the formation of granulated tissues and become POLYPoid mass. Herein, we describe a 52-year-old man with severe respiratory distress and infection with 35 years history of smoking. He had an obstructive pattern in his pulmonary function tests and severe bronchiectasis of right lower lobe that responded well to lobectomy with POLYPectomy. Pathologic examination revealed large endobronchial POLYP 9x2 cm obstructing right and left bronchi and right lower lobe bronchiectasis. Such large inflammatory endobronchial POLYP has rarely been presented in literature.

Herein we describe a rare case of a 59-year-old male who was diagnosed with giant hyperplastic POLYPs after referring with symptoms of abdominal pain and vomiting, and associated red-flag symptoms of unintentional weight loss and early satiety.

Aspirin exacerbated respiratory disease (AERD) is known by the triad of chronic rhinosinusitis with nasal POLYPosis (CRSwNP), aspirin hypersensitivity, and asthma, but its etiology and physiopathogenesis are still unclear. This cross-sectional study was designed to investigate allergy and inflammatory cells (neutrophils vs. eosinophils) dominancy in nasal POLYP tissue of patients with AERD compared to non-AERD patients. CRSwNP patients scheduled for endoscopic sinus surgery were recruited in this study. Nasal POLYP tissue was analyzed for infiltrating cells, and Eosinophil dominant and neutrophil dominant POLYPs were determined. AERD was confirmed by oral aspirin challenge (OAC). Demographics data; history of asthma, exacerbation by using NSAIDs, routine use of aspirin, type of surgery (primary or revision), and results of skin prick test and spirometry were recorded. Pathology results and contributing factors compared between AERD and non-AERD patients. Sixty-five patients (39 women, 26 men) were enrolled in the study (mean age 38. 83 ± 12. 43 years). Thirty (46%) patients had positive OAC tests. Totally 41 patients (63. 1%) had eosinophilic POLYPs. 80% of patients with eosinophilic POLYP had positive OAC and were AERD (P < 0. 05). There was no significant difference in demographics, revision surgery, and concomitant asthma between AERD and non-AERD groups (P > 0. 05). The positive skin prick test was higher in AERD and also in eosinophilic POLYP patients, but it was not statistically significant (P = 0. 086 and P = 0. 177). Eosinophilic POLYPs are more common in AERD. A positive skin prick test is associated with AERD and eosinophilic POLYP.

The gastric inflammatory fibroid POLYP (IFP) is a rare benign tumor of unknown etiology that is localized mainly in the antrum and presents endoscopically as submucosal mass. The lesion manifests as abdominal pain, weight loss, bleeding, dyspeptic symptoms, and iron deficiency anemia. We report a case of gastric IFP presented with microcytic anaemia, dyspepsia, malena and weight loss. Endoscopy revealed presence of a sessile gastric antral POLYP. A clinical diagnosis of gastric malignant POLYP was suspected. Microscopic examination revealed the presence of mononuclear fusiform fibroblast like cells, arranged in fascicles and whorl formation around vessels, in an inflammatory background rich in eosinophils. The fusiform cells appeared uniform and had abundant cytoplasm with pale spindle shaped nuclei. We highlight the case because of its rarity amongst the different types of gastrointestinal POLYPs and its unusual presentation like anaemia and weight loss withclinical suspicion of malignant gastric POLYP.

A case of gall bladder POLYP with heterotopic gastric mucosa in a gastric mucosa in a 35-year-old man who presented with recurrent right upper quadrant abdominal pain is reported. Ulrtasonography demonstrated a highly echogenic POLYPoid mass in the body of gallbladder. All other investigation results were normal. His symptoms resolved after laparoscopic cholecystectomy. Histologically, the POLYP was consisted of both fundic and pyloric type gastric glands located in the mucosa of POLYP. Up to knowledge of authors so far, 43 cases of heterotopic and gastric mucosa of gallbladder have been reported, only two cases, including the present case were found as a gall bladder POLYP.

Introduction Parotid gland squamous cell carcinoma is an uncommon aggressive neoplasm with poor prognosis. Aural POLYPs are usually the presenting features of chronic suppurative otitis media, tuberculous otitis media, and adenoma or carcinoma. The malignant aural POLYP is very rare. Parotid gland carcinoma masquerading as an aural POLYP has rarely been described in the literature. Case Report: We report a case study of parotid squamous cell carcinoma in a 29-year-old male masquerading as an ear POLYP. Conclusion: Parotid gland primary squamous cell carcinoma is a rapidly advancing neoplasm which carries poor prognosis despite multimodality treatment. Diligent clinical and histopathological evaluation is imperative to discriminate this rare aggressive disease from the metastatic and other primary cancers of the parotid. A high index of suspicion is crucial in refractory aural POLYPs to arrive at early diagnosis.