IN THE FIELD, POLYMERIC NANOPARTICLES HAVE BEEN EXTENSIVELY STUDIED AS PARTICULATE CARRIERS IN THE PHARMACEUTICAL AND MEDICAL FIELD. IN THIS INVESTIGATION, THE LIPID-CORE NANOCAPSULES WERE PREPARED BY INTERFACIAL DEPOSITION OF PREFORMED POLYMER. PCL, SUNFLOWER SEED OIL, PVA (POLYVINYL ALCOHOL), AND CORTISONE WERE DISSOLVED AT AMBIENT TEMPERATURE IN SUITABLE SOLVENT. THE ADVANTAGE OF THESE polyesterS IS THEIR BIOCOMPATIBILITY AND HIGHER HYDROLYSIS ABILITY INTO HUMAN BODY. MAJOR ACTIVITY IN THIS AREA HAS CENTERED ON ALIPHATIC polyesterS, PRINCIPALLY DUE TO THE FAVORAB TOXICOLOGY OF THEIR DEGRADATION PRODUCT BY UV, FT-IR AND SEM TECHNIQUES AND THEIR SUPERNATANT WERE USED FOR THE SPECTROSCOPIC SCAN ANALYSIS FROM 190 TO 800 NM. SEM CHARACTERISATION OF CORTISONE LOADED PCL NANOPARTICLES (FIG. A) AND PCL NANOPARTICLES (FIG. B). THE PARTICLE SIZE AND POLY DISPERSITY INDICES WERE MEASURED BY PHOTON CORRELATION SPECTROSCOPY. CORTISONE LOADED PCL NANOPARTICLES HAVE -24.5 MV ZETA POTENTIAL.CRITERIA FOR SELECTING A METHOD FOR PREPARATION OF NANOCAPSULES ACCORDING TO ITS ADVANTAGES, LIMITATIONS ANDBEHAVIOURS AS A DRUG CARRIER. [1-2]