With the formation of the Shiite state government, the Safavid government, in the beginning of 14th (A.D) century the Uzbecks of Dasht-i- Qepchaq occupied the north of Timurid territory in Mavry Alnahr and Kharazm areas. In both the areas, Sheibani clan and Arbashahi clan controlled the situation, respectively. In the beginning, in addition to their religious differences, the Uzbecks claimed Khorasan’s possession and this was the main cause of their conflict with Safavid. Although, Sheibani clan continued its hostile relations with Safavid until their extinction; the Arabshahi clan acted different in their relations with Safavid. Arabshahi’s relation with Safavid was based on a contradiction. The Arabshahi khan’s attacked the Safavid territory borders, murdered, plundered, captured Iranian Shiieas and sold them as slave. Arabshahi khan’s had a peaceful relationship with Safavid based on consensus and convergence; they exchanged ambassadors, also they released hostages and send them to Safavid court and kind of accepted Safavids as their foster. The attempt is made here to identify the internal evolutions in Khwarazm during Arabshahi rules and the correlation between Arabshahi khans and Safavid government with an emphasis on the affecting factors.