To study the effect of Soil Fertilizing Management on Seed Yield of thin walled pod pumpkin an experiment was conducted in agricultural farm of agronomy research center of Sanandaj based on factorial randomized complete block design with three replications. Treatments included levels of chemical fertilizer based on soil test (control zero, 50 and 100 percent of the recommended chemical fertilizer) and type of bio-fertilizers including no control application of organic fertilizer (compost), nitrocara, phosphate bio-fertilizer 2, and compound of compost+ nitrocara+ phosphate bio-fertilizer2. In this study, 1000-kernel weight, number of seeds per fruit, average weight per fruit were measured. Analysis of variance showed that the effects of chemical fertilizer on all traits, except for grain weight and number of fruits per plant were significant and also the biological fertilizer treatments had important impact on all traits except for seed weight, fruit diameter and number of fruits per plant. The interaction between organic fertilizer and biological fertilizer had significant effect on all traits except for seed weight and number of fruits per plant. Comparison of means showed that the combination of compost+ nitrocara+ phosphate fertile2 with 50% and 100% chemical fertilizer had the highest amount of number of seeds per fruit, fruit weight, fruit diameter, fruit yield and grain yield. In this research treatments of compost+ nitrocara+ phosphate bio-fertilizer 2 with 50% and 100% chemical fertilizer without bio-fertilizer and 43.38 percent in comparison with 100 percent chemical fertilizer without bio-fertilizer and 84.92 percent compared with control of both treatments. So, by using of compost+ nitrocara+ phosphate bio-fertilizer 2, can be saved 50 percent in consumption of chemical fertilizers.