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سال:1397 | دوره: | شماره: |تعداد مقالات:7

Background: Leishmaniasis is a parasitic disease originated from species of the genus Leishmania from the Trypanosomatidae family, with three main clinical forms of cutaneous, mucocutaneous and visceral. Every year, many new cases of the disease are reported in endemic areas. Nowadays, in non-endemic regions, the incidence of the disease has also created tension. Medicine side effects, reports of resistance against currently used drugs, and the absence of a putative vaccine have made researchers look for new effective drugs. The objective of the present study was to evaluate the effects of the ethanolic and aquatic extracts of the Ziziphora tenuior L. on the prolifration of Leishmania major amastigotes. Methods: The J774 cell lines were infected by promastigotes, at stationary phase, and treated with different concentrations of both extracts. After 12, 24 and 48 hours (h) at 37° C, the macrophages were stained with Giemsa, and the mean number of amastigotes in the macrophages was determined and compared with the control group. Finally, the ED50 of the extracts was calculated through statistical analysis. Results: Aquatic and ethanolic extracts of Ziziphora tenuior L. reduced the number of amastigotes within the macrophages. Following 48h of treatment, the ED50 of the aquatic and ethanolic extracts of the plant were 15. 75 mg/ml and 15 mg/ml, respectively. Hence, there was no significant difference between the ED50 of the aquatic and ethanolic extracts of the plant P<0. 05). Conclusion: Aquatic and ethanolic extracts of Ziziphora tenuior L. have a considerable anti Leishmania effect, hence the significance of further studies using the animal model of CL.

Background: Alopecia areata (AA) is a common localized nonscarring hair loss. Vitamin D and such trace elements as zinc have significant immunomodulatory roles and are reduced in many autoimmune diseases. We aim to evaluate the zinc and vitamin D levels in AA patients belonging to an Iranian population. Methods: We randomly recruited 77 patients with AA, and 112 age-and sex-matched normal subjects. Serum zinc and vitamin D levels were measured and compared between groups. Patients were considered vitamin D deficient or insufficient if 25-OH vitamin D levels were <10 and 10 to 30 ng/ml, respectively. Results: Disease duration was 6. 73± 1. 05 months. Compared to the control group, AA patients had significantly lower zinc (87. 78± 20. 61 vs. 92. 76± 28. 00, p=0. 008) and vitamin D levels (20. 23± 11. 11 vs. 25. 63± 15. 90, p=0. 01) and higher vitamin D deficiency (19. 5% vs. 10. 7%, p=0. 03). There were significant correlations between AA duration and zinc levels (r=0. 483, p<0. 001); no recognizable relationship, on the other hand, was observed with vitamin D levels (r=0. 022, p=0. 84). Conclusion: There were significantly lower levels of zinc and vitamin D in AA patients, compared to normal subjects. Zinc level is inversely correlated with disease duration, and both zinc and vitamin D play crucial roles in AA pathogenesis and are possible supplements in AA treatment.

Background: Nowadays, the rapid recovery of skin lesions and functional return are among the goals of researchers. The skin is the first defensive barrier against microorganisms in the body and its failure causes infection to spread in all systems of the body. By taking into account the contradictory results of previous studies on the impact of phototherapy on wound healing and also the considerable anti-oxidative properties of curcumin, this novel study was carried out with the aim of determining the histopathological impact of compact fluorescent light (CFL) and curcumin on the process of wound healing. Methods: Forty-eight adult male wistar rats were randomly divided into four groups. The control group received 2. 0 ml of ethyl oleate, and the curcumin group received only 0. 2 ml curcumin daily for 15 days via intraperitoneal injection. The fluorescent group received 0. 2 ml of ethyl oleate daily for 15 days via intraperitoneal injection, and were exposed to CFL for 12 hours per day for 15 days. The curcumin plus fluorescent group received 0. 2 ml curcumin daily for 15 days via intraperitoneal injection, and were exposed to CFL for 12 hours per day for 15 days. The size of the wound was measured by a scale ruler, and the morphology of the wound site was assessed. Results: The results of this study showed that the best percentage of repair was observed in the fluorescent group on days 6 and 15 (50± 5 and 90± 2, respectively), while the least repair was seen in the group receiving fluorescent plus curcumin (33± 7). In the curcumin group, the wound healing was, not significantly (P=0. 872) reduced on the sixth day, compared to the control group, whereas compared to the fluorescent and fluorescent plus curcumin groups, the reduction was significant (P? 0. 0001 and P=0. 05, respectively). On the fifteenth day, however, the wound healing was significantly decreased in the curcumin group compared to the control and fluorescent groups (P? 0. 0001 and P? 0. 0001 respectively), while it was significantly increased compared to the fluorescent plus curcumin group (P? 0. 0001). In the fluorescent plud curcumin group, the wound healing was significantly reduced compared to the other groups on the fifteenth day (P? 0. 0001). Conclusion: Fluorescent alone resulted in wound healing, in contrast to the control and curcumin plus fluorescent groups. Accelerating the repair in this group is likely due to the increase in blood flow and helping the homeostasis to return to its primary state. The absence of wound healing in the curcumin group is probably due to the high dose of curcumin. Moreover, in the fluorescent plus curcumin group, the causes of no wound healing and weight loss were probably disorders in the inflammation process and spread of infection.

Syringocystadenoma papilliferum is an uncommon benign apocrine gland tumour, mostly of congenital or early childhood onset, affecting head and neck. In addition, nevus sebaceous is commonly associated with this tumor. Here, we document three cases of syringocystadenoma papilliferum with many atypical features, such as the involvement of rare sites (abdomen, axilla and thigh), absence of nevus sebaceous and coexistence of tubular apocrine adenoma. The histopathologic characteristics were consistent with the diagnosis in all three cases.

Lymphangioma circumscriptum is a rare benign lymphatic malformation, clinically characterized by clusters of translucent vesicles. Uncommon manifestations such as verruciform or zosteriform have also been reported in the literature, yet eczematous-like presentation is extremely rare. The present study describes the case of a young woman with a 16-year history of an exudative eczematous-like plaque, mistreated as dermatitis which converted to a semi vesicular lesion during the treatment of super infection and was later diagnosed as lymphangioma circumscriptum by histopathology study. It is suggested that since lymphangioma circumscriptum may resemble other diseases such as dermatitis, histology, as the gold standard for diagnosis, should not be forgotten in the clinical context of this entity.

The use of high-power diode laser with a wavelength of 755 nm is an effective and safe method for the correction and partial and/or total elimination of pigmented lesions, specifically solar lentigines. This wavelength has yet not been used in diode lasers to treat solar lentigines. Side effects are the usual ones, including darkening and scab formation. Our patient was a 40-year-old woman of Caucasian origin and IV Fitzpatrick phototype, who presented with solar lentigines of different sizes and clear edges. The applied treatment was a high-power diode laser of 755 nanometer (nm), 21 millisecond (ms) long pulse and 25 J/cm2 fluence. Initially, the darkening of the lesion occurred, followed by the appearance of a scab, which remitted 10 days after. The use of high-power diode laser of single pulse at 755nm, 25J/ cm2 and 21ms, proved effective and safe concerning the removal of benign pigmented lesions.

CLINICAL PRESENTATION A 35-year-old woman presented to the dermatological clinic of Shahid-Faghihi Hospital with asymptomatic, bilateral and symmetrical erythematous patches on her lower extremities. On clinical examination, there were erythematous patches on the lateral and medial malleolar surfaces and superior to the medial malleolus, with no other complaints regarding pain or itching (Figures 1 and 2). She gave no relevant past medical history and was taking no medications. An incisional biopsy was carried out on one of the erythematous patches.